Research in Pharmaceutical Sciences، جلد ۷، شماره ۲، صفحات ۸۷-۹۴
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives
چکیده انگلیسی مقاله Quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. In this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution Alamar Blue ® Assay against six strains of bacteria (three Gram-positive and three Gram-negative) and three strains of fungi. Following a broth micro dilution minimum inhibitory concentration (MIC) test, Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) tests were performed. Cytotoxic effects of the compounds were measured using the MTT colorimetric assay on HeLa cell line. Results of antimicrobial screening showed that compounds had better bacteriostatic activity against Gram-negative bacteria. Results from MBC revealed that these compounds had more significant bacteriostatic than bactericidal activities. Nearly all screened compounds showed good activity against C. albicans and A. niger. Results from MFC indicated that these compounds had better fungistatic rather than fungicidal activities. The synthesized target molecules were found to exhibit different cytotoxicity in the range of 10 to 100 µM on HeLa cell line. Compounds 6 and 7 exhibited acceptable cytotoxicity approximately 50% at 10 µM concentration.
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نویسندگان مقاله | F Hassanzadeh
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran , 81746-73461


| E Jafari
Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan


| G H Hakimelahi


| M Rahmani Khajouei
Department of Microbiology, School of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran, 81746-73461


| M Jalali
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran , 81746-73461 Isfahan Pharmaceutical Sciences Research Center, Isfahan, Iran, 81746-73461


| G A Khodarahmi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/228
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955280.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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