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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۷۵-۱۸۹
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Freeze-thaw‐induced cross-linked PVA/chitosan for oxytetracycline-loaded wound dressing: the experimental design and optimization
چکیده انگلیسی مقاله Oxytetracycline is an antibiotic for the treatment of the infections caused by Gram-positive and Gram-negative microorganisms. Among novel formulations applied for damaged skin, hydrogels have shown to be superior as they can provide a moist environment for the wound. The purpose of this study was to prepare and evaluate the hydrogels of oxytetracycline consisted of polyvinyl alcohol (PVA) and chitosan polymers. A study design based on 4 factors and 3 levels was used for the preparation and evaluation of hydrogels formed by freeze-thaw (F-T) cycle using PVA and chitosan as a matrix-based wound dressing system. Furthermore, an experimental design was employed in order to study the effect of independent variables, namely drug amount (X 1 , 500-1000 mg), the amount of PVA (X 2 , 3.33-7.5%), the amount of chitosan (X 3 , 0.5-1%), and F-T cycle (X 4 , 3-7 cycles) on the dependent variables, including encapsulation efficiency, swelling index, adsorption of protein onto hydrogel surface, and skin permeation. The interaction of formulation variables had a significant effect on both physicochemical properties and permeation. Hydrogel microbial tests with sequential dilution method in Muller-Hinton broth medium were also carried out. The selected hydrogel (F6) containing 5% PVA, 0.75% chitosan, 1000 mg drug, and 3 F-T cycles was found to have increased encapsulation efficiency, gel strength, and higher skin permeation suitable for faster healing of wounds. Results showed the biological stability of oxytetracycline HCl in the hydrogel formulation with a lower dilution of the pure drug. Thus, oxytetracycline-loaded hydrogel could be a potential candidate to be used as a wound dressing system.
کلیدواژه‌های انگلیسی مقاله Chitosan,Hydrogel,Oxytetracycline,Polyvinyl alcohol,Skin.
نویسندگان مقاله | Farzaneh Lotfipour
3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Mitra Alami-Milani
3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. 4Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Sara Salatin
3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Aylin Hadavi
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran. 5Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Mitra Jelvehgari


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1893
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955267.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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