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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۲۲-۱۲۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Metformin attenuates oxidative stress and liver damage after bile duct ligation in rats
چکیده انگلیسی مقاله The aim of the current study was to investigate the antioxidative effect of metformin (MTF) on bile duct ligation (BDL)-induced hepatic disorder and histological damage in rats. The rats were divided into 4 groups including sham control (SC), BDL alone (BDL surgery), MTF1 (BDL surgery and administration of 250 mg/kg of MFM) and MTF2 (BDL surgery and administration of 500 mg/kg of MTF). After BDL, the animals treated with MTF by gavage for 10 days. Hematoxylin and eosin staining, biochemical analysis and oxidative stress markers were assayed to determine histological alterations, liver functions, and oxidant/antioxidant status. Hepatotoxicity was verified by remarkable increase in plasma levels of aminotransferases and alkaline phosphatase activity and liver histology 10 days after the BDL surgery. Our finding showed that treatment with MTF markedly reduced plasma alkaline phosphatase and alleviated liver injury indices ( P ≤ 0.05). Furthermore, BDL caused a considerable increase in the protein carbonyl and malondialdehyde content ( P ≤ 0.05). However, MTF reduces oxidative stress by constraining the protein oxidation and lipid peroxidation, and increases antioxidant reserve by increasing the ferric reducing ability of plasma and reducing glutathione levels. MTF exerts antioxidative effects in the liver fibrosis and may represent a hepato-protective effect when given to rats with BDL-induced hepatic injury.
کلیدواژه‌های انگلیسی مقاله Antioxidant,Cholestasis,Fibrosis,Metformin,Oxidative stress.
نویسندگان مقاله | Heibatollah Sadeghi
2Student Research Committee, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Fatemeh Jahanbazi
1Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Hossein Sadeghi
3Senior Resident of Pathology, Department of Pathology, Transplant Research Center, Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Navid Omidifar
1Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Behnam Alipoor
1Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Esmaeel Panahi Kokhdan
1Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Seyed Mehdi Mousavipoor
4Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America.


| Seyed Hossein Mousavi-Fard
1Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran. 5Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Amir Hossein Doustimotlagh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1887
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955261.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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