این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۲، صفحات ۹۳-۱۰۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles
چکیده انگلیسی مقاله Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life and its prolonged-release preparations are not available. Therefore, the main objective behind the present research work is to develop chitosan coated and conjugated poly (lactic-co-glycolic acid) (PLGA) nanocarriers, to sustain the delivery of FSM with improved systemic circulation. Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. In-vivo pharmacokinetic study showed 2.6, 3.10, and 4.30 folds enhancement in relative availability of FSM for FSM-PLGA, FSM-chitosan-coated-PLGA and FSM-chitosan-conjugated-PLGA nanoparticles, respectively than FSM. The present research work concluded that FSM loaded chitosan conjugated PLGA nanoparticles could enhance the systemic circulation of FSM with improved pharmacokinetics parameters.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Sapna Kashyap
1Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi -221005, India.


| Amit Singh
2School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi -221005, India.


| Abha Mishra
3Department of Chemical Engineering, Indian Institute of Technology-Delhi, New Delhi- 110016, India.


| Vikas Singh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1883
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1955258.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات