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Middle East Journal of Digestive Diseases، جلد ۱۱، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia
چکیده انگلیسی مقاله Anorectal melanomas are exceptionally uncommon and only 30% of anorectal melanomas are amelanotic. We report here a case of an anorectal amelanotic melanoma in a female patient. An 84-year-old patient complained of anal mass for 3 months. On examination, there was a 7.0 cm mass prolapsing through the anus that was pale-pink in color. Abdominal, pelvic, and chest computed tomography (CT) showed rectal wall thickening with an eccentric polypoid soft tissue density mass, and left inguinal and presacral lymph node enlargement along with a small nodule in the lower lobe of the left lung, likely representing metastatic deposit. Microscopic examination revealed a piece of skin with hyperplastic squamous epithelium with surface ulceration. The dermis and underlining tissue were showing infiltration by malignant sheets and nests of ovoid and spindle shape cells with prominent nucleolus and high mitotic figures. Immuno-staining for HMB-45, S-100, and Melan-A was positive, and it was negative for P63, CK 5/6, and Pan-CK, thus confirming it as an anorectal amelanotic melanoma, and not an epithelial tumor. This is the first case of an amelanotic anorectal melanoma reported from Saudi Arabia.
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نویسندگان مقاله | Khaled Ali Baniyaseen
Faculty of Medicine, Umm-Al-Qura University, Makkah, Saudi Arabia


| Muhammad Saeed
Histopathology Division, King Fahad Central Hospital, Jazan, Saudi Arabia


| Ahmed Omar Albonni
Department of Radiology, Al-Noor Specialty Hospital, Makkah, Saudi Arabia


| Bothaina Mohammed Abdulshakour
Medicine and Medical Sciences Research Center, Deanship of Scientific Research, Umm-Al-Qura University, Makkah, Saudi Arabia


| Ghida Dairi
1 Department of Medical Genetics, Umm-Al-Qura University, Saudi Arabia 2 Science and Technology Unit, Umm-Al-Qura University, Makkah, Saudi Arabia


| Faisal A. Al-Allaf
1 Department of Medical Genetics, Umm-Al-Qura University, Saudi Arabia 2 Science and Technology Unit, Umm-Al-Qura University, Makkah, Saudi Arabia


| Mohiuddin Mohammed Taher


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2066
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/332/article-332-1674715.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Case Report
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