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Iranian Journal of Medical Sciences، جلد ۳۲، شماره ۱، صفحات ۴۵-۴۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Orange, Tangerine, and Grapefruit Juices on Pharmacokinetic Parameters of Cyclosporine A in Rats |
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| چکیده انگلیسی مقاله |
This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporine A was given as a single oral dose (5 mg/kg). Blood samples (2 ml) were collected at 30, 120, and 240 min after administering cyclosporine A, and area under time-concentration curve (AUC), Maximal serum concentration (Cmax),and time to reach maximal concentration (Tmax) were calculated using one-compartment method. Orange juice, but not tangerine or grapefruit juices, significantly increased the AUC and Cmax of cyclosporine A compared with water. The three juices significantly decreased the Tmax of cyclosporine A. The findings suggest that Thompson Novel's orange juice increased the bioavailability of oral administration of cyclosporine A formulation in rats. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
Hadi Sorkhi |
A.A. Moghadamnia |
M. PourAmir |
A.R. Firoozjahi |
F. Oaliaee |
H. Karbalaee Aghamolki |
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| نشانی اینترنتی |
http://ijms.sums.ac.ir/article_43354_df41acb080565e1f5e10bcf4fb8364ac.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-1611553.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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