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Iranian Journal of Immunology، جلد ۱، شماره ۱، صفحات ۷۱-۷۵
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عنوان انگلیسی Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls
چکیده انگلیسی مقاله Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glutathione peroxides and changes in its plasma level has been proposed to be associated with allergic diseases. Materials and Methods: This study comprised of 21 cases of allergic asthma (AA), 33 cases of allergic rhinitis (AR) whose age and sex were matched with 28 healthy controls. IL-4, IL-10, IFN-g levels were tested by ELISA assay, and serum selenium was measured by atomic absorption spectorphotometery method. Results: Mean serum selenium level of AA and AR groups were lower than controls. Mean serum IL-4 level of AA was higher than the AR group. Mean serum IL-4 level of AA and AR group were higher than controls. Conclusion: The results of this study indicate that low selenium level may have a role in the pathogenesis of allergic diseases.
کلیدواژه‌های انگلیسی مقاله Allergic Rhinitis, Eosinophilia, prevalence
نویسندگان مقاله Reza Farid |
Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Farahzad Jabbari Azad |
Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Javad Gaffari |
Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Rangbar |
Koeln Immunology Research Center, Germany

Zahra Nikjoy |
Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی http://iji.sums.ac.ir/article_16710_275232b3681d3bfa4e90926bdb60acbb.pdf
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