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Iranian Journal of Medical Physics، جلد ۱۵، شماره Special Issue-۱۲th. Iranian Congress of Medical Physics، صفحات ۴۲۰-۴۲۰
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عنوان انگلیسی Enhancement of radio sensitization by gold-silica shell- core nanoparticle in MCF7 breast cancer cells
چکیده انگلیسی مقاله   Introduction: In the present study, we investigated the role of gold-silica shell-core nanoparticle in megavoltage irradiation of MCF7 breast cancer cells.   Materials and Methods: gold-silicon oxide shell-core nanoparticles (NPs) were obtained by conjugation of gold nanoparticle with amine or thiol functionalized silica nanoparticles (AuN@SiO2 and AuS@SiO2). The structure of each nanoparticle was fully characterized by FTIR and TEM. The NPs treated cells were irradiated by using 6 and 18 MV x-rays. MTT and Brdu assay, DAPI staining and cell cycle were used to evaluate efficiency of nanoparticle in radiation therapy. Results: The average size of AuN@SiO2 and AuS@SiO2 NPs was 23.79±7.04 and 31.28±7.37 nm, respectively. The Brdu findings revealed significantly more death in AuN@SiO2 (amine) treated and exposed cells compared to AuS@SiO2 (thiol) treated cells. (p< 0.05). Cell cycle study show that presence of NPs enhanced the effect of radiotherapy, in particular, highest destructive effects were observed at the radiation dose of 8 Gy using energy 18 MV.   Conclusion: It was concluded that our findings may open the possibilities for cooperative radiotherapy and gold-silica shell-core nanoparticle by increasing cytotoxicity in MCF7 cells and decreased side effect from single modality radiotherapy.
کلیدواژه‌های انگلیسی مقاله BreastCancer, Radiotherapy, Nanoparticle, MCF-7
نویسندگان مقاله | Ghazal Darfarin
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Roya Salehi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Science, Tabriz, Iran


| Effat Alizadeh
Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran


| Behnam Nasiri motlagh
Tabriz Valiasr Hospital, Department of Radiation Oncology, Tabriz, Iran


| Abolfazl Akbarzad
Tuberculosis and Lung Disease Research Center of Tabriz, Tabriz University of Medical Sciences Department of Chemical Engineering, Northeastern University, Boston, MA, USA


| Alireza Naseri
Faculty of Advanced Medical Sciences, Tabriz University of Medical Science, Tabriz, Iran


| Alireza Farajollahi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Physic, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Imam Reza University Hospital, Radiotherapy Department, Tabriz University of Medical sciences, Tabriz, Iran
نشانی اینترنتی http://ijmp.mums.ac.ir/article_13080.html
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