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Journal of Pharmaceutical Care، جلد ۴، شماره ۳-۴، صفحات ۷۰-۷۴
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عنوان انگلیسی Drug Use Evaluation of Human Intravenous Immunoglobulin (IVIG) in a Teaching Hospital in East of Iran
چکیده انگلیسی مقاله different indications that only a few of them is now approved by the Food and Drug Administration (FDA) as primary immunodeficiency, idiopathic thrombocytopenic purpura (ITP). Although it has been approved for selected indications, the list of its clinical indications, particularly off-labels, has grown considerably. Unfortunately, many of these conditions, lack sufficient clinical data of efficacy and might not always be appropriate. Method: It was a cross sectional study performed in Amir-al-momenin teaching hospital affiliated to Zabol University of medical sciences. All hospitalized patients who received IVIG during a 6 month period (autumn and winter 2015) were included in this study. We used predesigned data collection forms for data gathering as patient’s demographics, diagnoses, as well as drug related data, such as dose regimen, duration, rate of infusion, any related lab test. Results: In this study total of 49 patients received IVIG. Only in 25 cases, the mentioned indications were FDA approved (51%).Total of 189 IVIG vials (945 grams) that cost 146,475,000 Tomans (39481 USD) was administered during this study period, of which 560 grams (112vials) (59.2%) were used for FDA approved indications. From 19 ITP patients only 6 (12.2%) fulfilled the criteria for IVIG therapy. Considering cases of wrong doses and whom were not indicated to receive IVIG therapy, total of (93 vials) 465 grams, that cost 72,075,000 Tomans (19427 USD) were spent irrationally. Conclusion: We concluded that IVIG was widely used irrationally in our institution and cost of this irrational administration is huge. This fact justifies the need for establishing multidisciplinary supervisory procedure in our hospital.
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نویسندگان مقاله | Mandana Moradi
zabol university of medical sciences


| Talieh Moti
Student research committee, Faculty of pharmacy, Zabol University of Medical Sciences, Zabol, Iran
نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/172
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