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Journal of Pharmaceutical Care، جلد ۵، شماره ۱-۲، صفحات ۲-۶
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عنوان انگلیسی Prospective Drug Use Evaluation of Meropenem in a Teaching Referral Hospital, Mashhad, Iran
چکیده انگلیسی مقاله Introduction: Inappropriate use of antibiotic, leads to microbial resistance, nosocomial infections and increased hospital costs. Therefore, it is necessary to control and evaluate the use of these medications, especially broad-spectrum antibiotics. This study evaluated the pattern of meropenem utilization in Imam Reza hospital, Mashhad, Iran. Methods: First, a guideline for proper indications of meropenem was designed and finalized based on the clinical pharmacists and infectious disease specialist’s comments. One hundred patients were chosen randomly from different wards of the hospital and their data were recorded in predesigned questionnaires. Then, the pattern of meropenem consumption was analyzed according to the guideline. Results: This study was performed in 100 patients, including 48 women and 52 men. In 13 cases (13%), patients had no approved indication for meropenem. The initial regimens were changed in 6 cases (6%) based on culture results and in 73 cases (73%) relied on clinical response. In 64 cases (64%), administrated doses were compatible with prepared guideline. Renal dose adjustment was acceptable based on guideline only in 30% of patients with renal impairment (30 patients out of 100). Hyper-sensitivity reaction, one of the adverse reactions of meropenem, was seen in 1 patient (1%). Conclusion: According to the results, considerable errors occurred in meropenem administration and dosing. Therefore, it is necessary to design and implement a localized guideline for meropenem consumption in Imam Reza hospital of Mashhad, Iran.
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نویسندگان مقاله | Fatemeh Naseri
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Nasser Vahdati-Mashhadian
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
 3 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammad Reza Saberi
Medical Chemistry Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Amir Hooshang Mohammadpour
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Sepideh Elyasi
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/176
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