این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Cancer Research، جلد ۳، شماره ۱، صفحات ۵۲-۵۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Establishment of Autochthonous & Standard Cell Line Derived Xenograft Models of Glioblastoma Multiform in Iran
چکیده انگلیسی مقاله Background: GBM is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. Several researchers around the world, including Iran, have been investigated GBM-cell line in vitro. However in vivo studies have not been fulfilled. Methods: As standard cell line (U-87MG) derived from human GBM and total GBM tumor derived from 3 patients were heterotypic ally injected into 4-6 weeks old athymic nude mice.  Pathologic investigation by H&E, GFAP and Ki-67 were examined 2 months post implantation. Results: GBM characteristics appeared in H&E and GFAP and the rate of proliferation was 6% and in direct xenograft tumor was 9% which was consistent with the pathologic result of patient. Conclusion: GBM Xengraft is the most suitable model for in vivo investigation and researcher can evaluate new treatments for this tumor. On the other hands, Pharmacogenomics differences in treatment response could be indicated among Iranians.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Ali-Reza Khoshnevisan
Iranian Center of Neurological Research, Tehran University of Medical Sciences


| Ahad Muhammadnejad
Cancer Research Center, Tehran University of Medical Sciences


| Samad Muhammadnejad
Cancer Research Center, Tehran University of Medical Sciences


| Zohreh Mazaheri
Cancer Research Center, Tehran University of Medical Sciences


| Maryam Kazem haghighi
Cancer Research Center, Tehran University of Medical Sciences


| Farrokh Tirgari
Cancer Research Center, Tehran University of Medical Sciences


| Mohammad-Ali Oghabian
Research Center Sciences Technology in Medicine, Tehran University of Medical Sciences


| Saeid Amanpour
Cancer Research Center, Tehran University of Medical Sciences
نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/8
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/151/article-151-1355038.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات