Iranian Journal of Parasitology، جلد ۱۰، شماره ۲، صفحات ۱۷۱-۱۸۰
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عنوان انگلیسی Anti-Toxoplasma Activity of 2-(Naphthalene-2-γlthiol)-1H Indole.
چکیده انگلیسی مقاله Background:This study was undertaken to evaluate the viability, infectivity and immunity of Toxoplasma gondii tachyzoites exposed to 2-(naphthalene-2-ylthio)-1H-indole.  Methods:Tachyzoites of RH strain were incubated in various concentrations of 2- (naphthalene-2-ylthio)-1H-indole (25-800μM) for 1.5 hours. Then, they were stained by PI and analyzed by Fluorescence-activated cell sorting (FACS). To eval-uate the infectivity, the tachyzoites exposed to the different concentrations of the compound were inoculated to 10 BALB/c mice groups. For Control, parasites ex-posed to DMSO (0.2% v/v) were also intraperitoneally inoculated into two groups of mice. The immunity of the exposed tachyzoites was evaluated by inoculation of the naïve parasite to the survived mice. Results:The LD50 of 2-(naphthalene-2-ylthio)-1H-indole was 57 μmol. The lon-gevity of mice was dose dependent. Five mice out of group 400μmol and 3 out of group 800μmol showed immunization to the parasite.  Conclusion:Our findings demonstrated the toxoplasmocidal activity of the com-pound. The presence of a well-organized transporter mechanism for indole com-pounds within the parasite in conjunction with several effective mechanisms of these compounds on Toxoplasma viability would open a window for production of new drugs and vaccines.
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نویسندگان مقاله | Qasem Asgari
Dept. of Parasitology and Mycology, Shiraz University of Medical Sciences, Shiraz, Iran.


| Hossein Keshavarz
Dept. of Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran.


| Mostafa Rezaeian
Dept. of Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran.


| Hossein Sadeghpour
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Dept. of Medicinal Chemistry of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.


| Ramin Miri
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Dept. of Medicinal Chemistry of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mohammad Hossein Motazedian
Dept. of Parasitology and Mycology, Shiraz University of Medical Sciences, Shiraz, Iran.
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/335
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