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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۲، شماره ۱، صفحات ۱۱-۰
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عنوان انگلیسی HER2/neu and αSMA Expression in Oral Squamous Cell Carcinoma
چکیده انگلیسی مقاله Statement of Problem: Squamous cell carcinoma (SCC) is the most common cancer of the mouth, but its pathogenesis is unknown. HER2/neu is a protoncogene with homologue sequence with EGF. αSMA is a smooth muscle specific actin which indicates the existence of myofibroblasts in the oral cancer stroma. Purpose: This study aimed to measure the frequency of Her2/neu and (alpha) αSMA in oral SCC. Materials and Method: For this study, 18 paraffinized blocks of OSCC were immunostained with Anti HER2/neu, Anti (Alpha) SMA. Percentage and degree of the epithelial cells staining and percentage staining of myofibroblasts were considered. The results of the study were analyzed using kappa and X 2 . Results: From 18 cases of OSCC, 3 and 12 cases were positive with HER2/neu and αSMA, respectively. In the normal oral mucosa, one case was positive (Score 2) with HER2/neu but αSMA positive myofibroblasts were not seen in the stroma of OSCC. A significant difference was seen in αSMA expression in OSCC and the normal oral mucosa ( p =0.002). No significant difference was found in HER2/neu expression in OSCC and normal mucosa ( p >0.05). Conclusion: The results of this study suggest that αSMA has an effective role in pathogenesis and aggressive behavior of OSCC but HER2/neu has no main role in this type of oral cancer.
کلیدواژه‌های انگلیسی مقاله Squamous Cell Carcinoma, HER2/neu, αSMA, Myofibroblast
نویسندگان مقاله s سیفی | s seifi
dept. of oral and maxillofacial pathology, school of dentistry, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

sh شفایی | sh shafaie
dept. of pathology, school of medicine, babol university of medical sciences, babol

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/127
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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