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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۵، صفحات ۴۶۹-۴۷۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The role of hormones in renal disease and ischemia-reperfusion injury |
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| چکیده انگلیسی مقاله |
The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation is considered the choice treatment for patients with ESRD. Ischemia-reperfusion (IR), which occurs during renal transplantation is one of the factors that affect the outcome of renal transplantation. Renal graft rejection is the result of IR injury and there is no effective treatment to prevent IR injury. Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). Thus, antioxidant, anti-apoptotic and anti-inflammatory hormones, which inhibit these pathways, can protect against IR injury and improve transplanted renal function in patients with ESRD. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Shokofeh Banaei
Social Determinants of Health (SDH) Research Center, Ardabil University of Medical Sciences, Ardabil, Iran|Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
| Lotfollah Rezagholizadeh
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_12448.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1339843.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article |
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