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Journal of Kerman University of Medical Sciences، جلد ۲۵، شماره ۶، صفحات ۴۶۲-۴۷۰
عنوان فارسی مقایسه دو روش درمانی: متوترکسات فولینیک اسید (۸ روز) و متوتروکسات هفتگی در بیماران مبتلا به نئوپلاسی تروفوبلاستیک کم هزینه
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عنوان انگلیسی Comparison of Two Therapeutic Regimens: Methotrexate-Folinic Acid (8 days) and Weekly Methotrexate in Patients with Low risk Gestational Trophoblastic neoplasia
چکیده انگلیسی مقاله Background: Methotrexate is used in the treatment of Low-risk Gestational Trophoblastic Neoplasia. The purpose of this study was to compare the therapeutic responses and side effects of two therapeutic methods which were prescribed for patients suffering from Low-risk Gestational Trophoblastic Neoplasia. One method was the daily use of Methotrexate-Folic Acid (for 8 days) and the other was the weekly use of Methotrexate. Methods:This study is a randomized double-blind clinical trial which was undertaken on 122 patients suffering from Low-risk Gestational Trophoblastic Neoplasia, who referred to AfzaliPoor Hospital in Kerman City, Iran. The patients were randomly divided into two groups: one group took Methotrexate-Folic Acid daily for a period of 8 days (muscular taking of one milligram/kilogram of Methotrexate in days 1,3,5 and 7; and 0.1 milligram/kilogram of Folic Acid in days 2,4,6 and 8); the other group took the same medication weekly (muscular taking of 30 to 50 milligrams per each square meter of body mass every week). Results: Findings showed that 95% of the patients effectively responded to the 8-day regimen and 90% responded to weekly regimen. Five percent of the 8-day regimen group and 10% of the weekly regimen group needed a second treatment. This difference was not significant. Concerning the related side effects, only one patient in the weekly regimen group experienced nausea and vomiting, and one patient experienced neutropenia; while 4 patients in the 8-day regimen group experienced nausea and vomiting, one patient had mucositis, 2 patients had conjunctivitis, two patients experienced neutropenia, and one patient had thrombocytopenia. Conclusions: Considering the related costs, the 8-day regimen was significantly more economical and affordable than the weekly regimen.
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نویسندگان مقاله zahra honarvar |
Assistant professor, Fellowship of Gyneco-Oncology, Kerman University of Medical Sciences, Kerman, Iran

Maryam Masoumi |
MD. Obstetrics & Gynecology, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_85234_4d7016dbf7d7ee9ddad2cd0d498ed151.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-1337174.pdf
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