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Journal of Kerman University of Medical Sciences، جلد ۲۵، شماره ۵، صفحات ۳۸۲-۳۸۹
عنوان فارسی تنظیم مقیاس وریدی HOTAIR در بافت تومور زنان ایرانی مبتلا به سرطان پستان
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Upregulation of HOTAIR Transcript Level in Tumor Tissue of Iranian Women with Breast Cancer
چکیده انگلیسی مقاله Background:Dysregulation of HOX Transcript Antisense Intergenic RNA (HOTAIR) has been linked to the etiopathogenesis of several human cancers. According to epidemiological evidences, the risk of susceptibility to breast cancer varies among different populations. This study was designed to determine the transcriptional level of HOTAIR in tumor cells of breast cancer patients compared to normal marginal cells and to identify if this molecule has the potential to be considered as a biomarker in the prognosis of breast cancer. Methods:A total of 37 patients with breast cancer were recruited. Tumor and matched normal tumor-free margin samples were collected during surgery from each patient. Following total RNA extraction and cDNA synthesis, quantitative analysis was performed by real-time PCR using the SYBR Green PCR Master Mix to determine the transcript level of HOTAIR in samples. Results:It was observed that mRNA expression level of HOTAIR was upregulated in tumor cells compared with normal tumor free marginal cells of breast cancer patients (Fold change= +6.9; P = 0.0001). However, no statistically significant correlations were observed between the mRNA expression level of HOTAIR and clinicopathological manifestations of the patients. Conclusions:The results were in accord with what had previously been reported and therefore, it can be concluded that in Iranian population, too, HOTAIR is upregulated in tumor cells of breast cancer patients and has the potential to be considered as a biomarker for the prognosis of breast cancer.
کلیدواژه‌های انگلیسی مقاله Breast Cancer, HOTAIR, mRNA expression, Cancer biomarker
نویسندگان مقاله Sorayya Mohammadi-kechikaghi |
Master of Science, Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Mohammad Ali HosseinpourFeizi |
Professor, Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Nasser Pouladi |
Assistant Professor, Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Mohammad Khalaj-Kondori |
Associate Professor, Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Mojtaba Shavali |
Department of Biology, Faculty of Science, Azerbaijan Shahid Madani University, Tabriz, Iran

Parvin Azarfam |
Master of Science, Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_83077_f00e41a449db767d2b10241eae89b77f.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-1291496.pdf
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