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Medical Journal of Islamic Republic of Iran، جلد ۱۲، شماره ۱، صفحات ۶۵-۶۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
MORPHOLOGICA L STUDY OF MOUSE (BALB/c) THYMUS A FTER HIGH A ND LOW DOSE DEXA METHA SONE TREATMENT |
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| چکیده انگلیسی مقاله |
Dexamethasone induces thymic atrophy and thymocyte apoptosis. In the present study histological and ultrastructural changes which occur in the thymus of the mouse (BALB/c) following treatment with high (20 mg/kg) and low (8 mg/kg) doses of dexamethasone were investigated. In low dose treated mice, apoptotic cells were observed focally and localized mainly in thymic nurse cells (T.N.C.). A zone of intact thymocytes was formed in the medulla of animals receiving 20 mg/kg of dexamethasone as well as an increase in trans-endothelial vesicles and a decrease in the size of the vesicles in the cortical capillaries. The enveloped thymocytes within thymic nurse cells respond to dexamethasone through apoptosis, and these changes were seen to be more severe in mice treated with high doses of dexamethasone. The formation of apoptotic cells in the thymus caused by low dose dexamethasone mimics the physiological process of cell death. Differential effects of low dose and high dose dexamethasone may have pharmacological and immunological implications. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
b نیک نفس | b niknafs
from the department of anatomy, faculty of medical sciences, tarbiat modarres university, tehran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
tm تاکی | tm taki
from the department of anatomy, faculty of medical sciences, tarbiat modarres university, tehran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
m رضازاده | m rezazadeh
from the department of anatomy, faculty of medical sciences, tarbiat modarres university, tehran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)
mh علیمحمدیان | mh alimohammadian
the departmenl of immunology, pasteur institute, tehran, islamic republic of iran.
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
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| نشانی اینترنتی |
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-499&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Anatomical Sciences |
| نوع مقاله منتشر شده |
Original Research: Basic Science in Medicine |
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