این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۳، صفحات ۲۹۶-۳۰۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method
چکیده انگلیسی مقاله Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo. Materials and Methods: Fourteen days after intraperitoneal injection of lentinan, rats were given an oral dose of a cocktail solution containing phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam. Then, we obtained blood in specific durations for the determination of plasma concentration of the probe drugs using UPLC-MS/MS. We also evaluated the pharmacokinetic parameters using the DAS 2.0 software. Results: We found that various concentrations of lentinan increased the activity of rat CYP1A2, CYP3A4, CYP2D6, and CYP2C19 but not CYP2C9. Conclusion: These findings suggest that clinical application of lentinan combination with CYP3A4, CYP1A2, CYP2C19, or CYP2D6 should be given careful consideration as this may lead to herb-drug interactions and hence treatment failure.
کلیدواژه‌های انگلیسی مقاله Cocktail, CYP, Herb-drug interaction, Lentinan, Probe drug
نویسندگان مقاله | Yiping Lin
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Yanli Wei
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Xiaoxia Hu
Jinhua Central Hospital, Jinhua 321000, Zhejiang, China


| Mei-Ling Wu
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Jingchan Yao
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Xiaoqian Ying
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Xiaoyan Fu
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Mingxing Ding
Jinhua Polytechnic, Jinhua 321007, Zhejiang, China


| Liman Qiao
The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12194.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1224110.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات