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Gene, Cell and Tissue، جلد ۳، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
MIR۱۷HG Gene Polymorphism and the Risk of Recurrent Spontaneous Abortion |
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| چکیده فارسی مقاله |
Materials and Methods The case and control groups were studied for the association between polymorphism of MIR17HG and recurrent pregnancy loss in Iranian females. One-hundred patients with recurrent abortions (at least two) as cases and one-hundred healthy female with two or more normal term deliveries and without a history of abortion were selected as controls. Total genomic DNA was isolated from blood leukocytes. SNPs were studied with Alu1 as a restriction enzyme. Results Results of the present study indicated significant association between rs6492538 polymorphism and recurrent pregnancy loss (P > 0.05). Conclusions The results of the present study provide evidence for association between genetic variation in MIR17HG and recurrent spontaneous abortion. Further studies will be required to validate the significance of the studied genetic variation in diverse populations and its regulatory role on target genes. Background Recurrent pregnancy loss (RPL) is two or more consecutive pregnancy losses before 20 weeks of gestation. So far the disease is known for a variety of reasons, but still about 50% of recurrent pregnancy losses are unknown. The miRNAs are a family of 20 - 25 nucleotide RNA that inhibit translation of the target gene or mRNA degradation and play a key role in a variety of regulatory pathways. The miRNA is involved in embryonic developments and regulatory disorders which cause numerous diseases including heart diseases and pregnancy-associated disorders. Recent studies suggest that common genetic factors may exist between ischemic heart disease and abortion. Objectives The current study aimed to investigate the relationship between rs6492538 polymorphism of MIR17HG gene and recurrent spontaneous abortion, which might be clinically useful as a marker to assess risks for recurrent pregnancy loss to provide good health care during pregnancy. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
MIR17HG Gene Polymorphism and the Risk of Recurrent Spontaneous Abortion |
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| چکیده انگلیسی مقاله |
Materials and Methods The case and control groups were studied for the association between polymorphism of MIR17HG and recurrent pregnancy loss in Iranian females. One-hundred patients with recurrent abortions (at least two) as cases and one-hundred healthy female with two or more normal term deliveries and without a history of abortion were selected as controls. Total genomic DNA was isolated from blood leukocytes. SNPs were studied with Alu1 as a restriction enzyme. Results Results of the present study indicated significant association between rs6492538 polymorphism and recurrent pregnancy loss (P > 0.05). Conclusions The results of the present study provide evidence for association between genetic variation in MIR17HG and recurrent spontaneous abortion. Further studies will be required to validate the significance of the studied genetic variation in diverse populations and its regulatory role on target genes. Background Recurrent pregnancy loss (RPL) is two or more consecutive pregnancy losses before 20 weeks of gestation. So far the disease is known for a variety of reasons, but still about 50% of recurrent pregnancy losses are unknown. The miRNAs are a family of 20 - 25 nucleotide RNA that inhibit translation of the target gene or mRNA degradation and play a key role in a variety of regulatory pathways. The miRNA is involved in embryonic developments and regulatory disorders which cause numerous diseases including heart diseases and pregnancy-associated disorders. Recent studies suggest that common genetic factors may exist between ischemic heart disease and abortion. Objectives The current study aimed to investigate the relationship between rs6492538 polymorphism of MIR17HG gene and recurrent spontaneous abortion, which might be clinically useful as a marker to assess risks for recurrent pregnancy loss to provide good health care during pregnancy. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
فاطمه شاکرمی | fatemeh shakarami
department of biology, guilan university, rasht, ir iran
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
رضا میرفخرایی | reza mirfakhraie
department of medical genetics, shahid beheshti university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
شهره زارع کاریزی | shohreh zare karizi
department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran; department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran. tel 98-9125953602
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
هانیه زارع | hanieh zare
department of biology, varamin pishva branch, islamic azad university, pishva, varamin, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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| نشانی اینترنتی |
http://www.genecelltissue.com/index.php?page=article&article_id=34526 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/gct-34526 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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