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Avicenna Journal of Medical Biochemistry، جلد ۲، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Hydro-alcoholic Extract of Commiphora mukul Gum Resin May Improve Cognitive Impairments in Diabetic Rats |
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| چکیده فارسی مقاله |
Materials and Methods Thirty-two adult male Wistar rats were randomly allocated to four groups: normal, diabetic, normal + extract of C. mukul and diabetic + extract of C. mukul groups with free access to regular rat diet. Diabetes was induced in male rats by single interaperitoneal injection of 60 mg/kg STZ. After the confirmation of diabetes, 300 mg/kg C. mukul extract was orally administered to the extract-treated groups. Control groups received normal saline at the same time. Passive-avoidance memory was tested eight weeks after the STZ treatment, and blood glucose and body weight were measured in all groups at the beginning and end of the experiment. Conclusions Commiphora mukul extract can improve passive-avoidance learning and memory impairments in the STZ-induced diabetic rats. This improvement may be due to the antioxidant, acetylcholinesterase inhibitory activity, anti-inflammatory or power to reduce hyperglycemia and lowering cholesterol and triglyceride properties of this extract. The result of this study is a promising point for new therapeutic alternatives in alleviating cognitive impairments caused by diabetes. Results In the present study, diabetes decreased learning and memory. Although the administration of C. mukul extract did not affect the step-through latency (STLa) and the number of trials of the diabetic groups during the first acquisition trial, a significant decrease was observed in STLr and also a significant increase in time spent in the dark compartment (TDC) and number of crossing (NOC) in the retention test (after 24 and 48 hours). Although no significant difference was observed in body weight of diabetic + extract of C. mukul (DE) and diabetic control (DC) groups, the plasma glucose of DE group was significantly lower in comparison to DC group. Objectives This study aimed to examine the effect of hydro- alcoholic extract of C. mukul on passive-avoidance learning and memory in streptozotocin (STZ) induced diabetic male rats. Background Diabetes causes cognitive impairment. Medicinal plants due to different mechanisms, such as antioxidant activities may improve diabetes and relieve its symptoms. Commiphora mukul (Burseraceae) has a significant antioxidant activity. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Hydro-alcoholic Extract of Commiphora mukul Gum Resin May Improve Cognitive Impairments in Diabetic Rats |
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| چکیده انگلیسی مقاله |
Materials and Methods Thirty-two adult male Wistar rats were randomly allocated to four groups: normal, diabetic, normal + extract of C. mukul and diabetic + extract of C. mukul groups with free access to regular rat diet. Diabetes was induced in male rats by single interaperitoneal injection of 60 mg/kg STZ. After the confirmation of diabetes, 300 mg/kg C. mukul extract was orally administered to the extract-treated groups. Control groups received normal saline at the same time. Passive-avoidance memory was tested eight weeks after the STZ treatment, and blood glucose and body weight were measured in all groups at the beginning and end of the experiment. Conclusions Commiphora mukul extract can improve passive-avoidance learning and memory impairments in the STZ-induced diabetic rats. This improvement may be due to the antioxidant, acetylcholinesterase inhibitory activity, anti-inflammatory or power to reduce hyperglycemia and lowering cholesterol and triglyceride properties of this extract. The result of this study is a promising point for new therapeutic alternatives in alleviating cognitive impairments caused by diabetes. Results In the present study, diabetes decreased learning and memory. Although the administration of C. mukul extract did not affect the step-through latency (STLa) and the number of trials of the diabetic groups during the first acquisition trial, a significant decrease was observed in STLr and also a significant increase in time spent in the dark compartment (TDC) and number of crossing (NOC) in the retention test (after 24 and 48 hours). Although no significant difference was observed in body weight of diabetic + extract of C. mukul (DE) and diabetic control (DC) groups, the plasma glucose of DE group was significantly lower in comparison to DC group. Objectives This study aimed to examine the effect of hydro- alcoholic extract of C. mukul on passive-avoidance learning and memory in streptozotocin (STZ) induced diabetic male rats. Background Diabetes causes cognitive impairment. Medicinal plants due to different mechanisms, such as antioxidant activities may improve diabetes and relieve its symptoms. Commiphora mukul (Burseraceae) has a significant antioxidant activity. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ایرج صالحی | iraj salehi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
زهرا taheraslani | zahra taheraslani
department of physiology, school of basic sciences, hamadan branch, islamic azad university, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
شیرین مرادخانی | shirin moradkhani
department of pharmacognosy and pharmaceutical biotechnology, school of pharmacy, hamadan university of medical sciences, hamadan, ir iran; department of pharmacognosy and pharmaceutical biotechnology, school of pharmacy, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138381593, fax 98-8138380031
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=24906 |
| فایل مقاله |
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| کد مقاله (doi) |
10.17795/ajmb-24906 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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