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Reports of Biochemistry and Molecular Biology، جلد ۱، شماره ۲، صفحات ۴۳-۴۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Comparison of Th1 and Th2 Responses in Non-Healing and Healing Patients with Cutaneous Leishmaniasis |
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| چکیده انگلیسی مقاله |
Background: Cutaneous leishmaniasis is an endemic disease in many regions of Iran, including the city of Mashhad. In recent years, some cases have not responded to Glucantime, the usual treatment for this disease. The cellular immune response caused by T-helper type 1 (Th1) cells has an important role in protection against leishmaniasis, and activation of the T-helper type 2 (Th2) response causes progression of the disease. By analyzing these responses we hope to find a more effective treatment than that currently in use for leishmaniasis patients. Methods: The cellular immune responses in 60 cases of non-healing and healing cutaneous leishmaniasis, and individuals in a control group, were analyzed by measuring cytokines released by peripheral blood mononuclear cells (PBMCs) when stimulated with Leishmania major antigens by Enzyme Linked Immuno Sorbent Assay (ELISA). Results: Subjects from the healing group secreted more interleukin-12 (IL-12) and interferon gamma (IFN-γ) (p< 0.05) and less interleukins -4, -5, -10 (IL-4, IL-5, and IL-10) (p< 0.005) and -18 (IL-18) (p=0.003) than the non-healing group. Conclusions: The results demonstrate that secretion of cytokines that activate Th2 response including IL-4, IL-5 and IL-10 in non-healing subjects was higher than healing subjects and secretion of cytokines that activate Th1 response including IL-12 and IFN-γ in healing subjects was higher relative to the non-healing subjects. In this study it has been shown that the level of IL-18 progresses disease in non-healing patients when the level of IL-12 gets decreased. |
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| کلیدواژه‌های انگلیسی مقاله |
Cutaneous leishmaniasis, Cytokines, Glucantime |
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| نویسندگان مقاله |
مریم شاهی | maryam shahi
tel 98 02633 311122511; fax 98 511- 5091172
مسعود مهاجری | masoud mohajery
parasitology amp;amp; medical mycology department, mashhad university of medical sciences mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
سید علی اکبر شمسیان | seyyed ali akbar shamsian
parasitology amp;amp; medical mycology department, mashhad university of medical sciences mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
حسین نهروانیان | hossein nahrevanian
parasitology departmen, pasteur institute of iran, tehran, iran.
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
سیدمحمدجواد یزدان پناه | seyyed mohammad javad yazdanpanah
parasitology amp;amp; medical mycology department, mashhad university of medical sciences mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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| نشانی اینترنتی |
http://www.rbmb.net/browse.php?a_code=A-10-1-8&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
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