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Middle East Journal of Digestive Diseases، جلد ۶، شماره ۴، صفحات ۱۸۶-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cohort Profile: Golestan Hepatitis B Cohort Study-A Prospective Long Term Study in Northern Iran |
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| چکیده انگلیسی مقاله |
Hepatitis B virus (HBV) infection is the most common cause of end stage liver disease in Iran and in Golestan province. Large-scale population-based prospective cohort studies with long term follow-up are the method of choice to accurately understand the natural course of HBV infection. To date, several studies of HBV epidemiology, natural history, progression to cirrhosis and association with HCC have been reported from other countries. However, few of these are prospective and fewer still are population-based. Moreover, the underlying molecular mechanisms and immunogenetic determinants of the outcome of HBV infection especially in low and middle income countries remains largely unknown. Therefore, the hepatitis B cohort study (HBCS), nested as part of the Golestan Cohort Study (GCS), Golestan, Iran was established in 2008 with the objective to prospectively investigate the natural course of chronic hepatitis B with reference to its epidemiology, viral/host genetic interactions, clinical features and outcome in the Middle East where genotype D HBV accounts for >90% of infections. In 2008, a baseline measurement of HBV surface antigen (HBsAg) was performed on stored serum samples of all GCS participants. A sub-cohort of 3,505 individuals were found to be HBsAg positive and were enrolled in the Golestan HBCS. In 2011, all first degree relatives of HBsAg positive subjects including their children and spouses were invited for HBV serology screening and those who were positive for HBsAg were also included in the Golestan HBCS. |
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| کلیدواژه‌های انگلیسی مقاله |
Hepatitis B virus,Golestan Cohort Profile,Serology screening |
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| نویسندگان مقاله |
اعظم کتونی زاده | aezam katoonizadeh
حسین پوستچی | hossein poustchi
محمد رضا ostovaneh | mohammad reza ostovaneh
شیرین موسوی | shirin moossavi
مریم شرفخواه | maryam sharafkhah
سعید اسماعیلی | saeed esmaili
اکرم پورشمس | akram pourshams
اشرف محمدخانی | ashraf mohamadkhani
سیما بشارت | sima besharat
شاهین مرآت | shahin merat
مهدی محمدنژاد | mehdi mohamadnejad
یعقوب ژورژ | jacob george
رضا ملک زاده | reza malekzadeh
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| نشانی اینترنتی |
http://www.mejdd.org/index.php/mejdd/article/view/1387 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Cohort Profile |
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