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Middle East Journal of Digestive Diseases، جلد ۶، شماره ۴، صفحات ۱۷۷-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Systematic Review of Zinc Biomarkers and Esophageal Cancer Risk |
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| چکیده انگلیسی مقاله |
BACKGROUND: It is hypothesized that poor zinc nutritional status is associated with an increased risk of esophageal cancer (EC), but current evidence is contradictory. Since some factors may influence zinc absorption, its status may be better evaluated thorough biomarkers. The objectives of this study were to perform a systematic review on the association of zinc biomarkers with EC in observational studies and to evaluate the efficacy of zinc supplements in preventing EC in randomized trials. METHODS: The MEDLINE database was searched in December 2013 for studies written in English with relevant keywords. Articles which met inclusion criteria were included in this study. RESULTS: Eleven observational studies that measured zinc biomarkers and eight randomized trials which evaluated supplements containing zinc, met our inclusion criteria. The majority of studies suggested that higher zinc status was inversely associated with EC risk. CONCLUSION: Most of the evidence for this hypothesis comes from case-control studies, which may introduce bias. Cohort studies are needed to establish whether poor zinc status is associated with increased risk for EC. Findings from trials are inconclusive as there is no data from single agent trials. However, the evidence is not still strong enough to conclude a protective role of zinc in EC. |
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| کلیدواژه‌های انگلیسی مقاله |
Zinc,Esophageal cancer,Minerals,Systematic review |
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| نویسندگان مقاله |
مریم هاشمیان | maryam hashemian
دکتر آزیتا حکمت دوست | azita hekmatdoost
حسین پوستچی | hossein poustchi
فاطمه محمدی نصرآبادی | fatemeh mohammadi nasrabadi
کریستین c abnet | christian c abnet
رضا ملک زاده | reza malekzadeh
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| نشانی اینترنتی |
http://www.mejdd.org/index.php/mejdd/article/view/1391 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Systematic Review |
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