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Middle East Journal of Digestive Diseases، جلد ۸، شماره ۴، صفحات ۲۸۹-۰
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عنوان انگلیسی The Effect of Zinc Supplementationon the Symptoms of gastroesophageal Reflux Disease; a Randomized Clinical Trial
چکیده انگلیسی مقاله BACKGROUND Currently, it has been demonstrated that gastroesophageal reflux disease (GERD) is one of the most important disorders of the digestive system and the commixture of regular diet has a significant influence on its incidence, symptoms, and prognosis. The purpose of this study was to evaluate the effect of zinc supplementation, in combination with PPIs(Proton pump inhibitors), on the improvement of GERD symptoms. METHODS In a randomized double blind clinical trial, patients with reflux symptoms, who had obtained Reflux Disease Questionnaire (RDQ) score more than 8, were included and all the demographic features were recorded. Then, using upper gastrointestinal (GI) endoscopy, all the patientswere divided into two groups as having non-erosive reflux disorder (NERD),or erosive reflux disorder (ERD). At the next step, based on random block statistical method, we divided the two groups into two subgroups; the drug subgroup [treated with PPIs (40 mg pantoprazole/daily), changing life style, and 220 mg zinc capsules daily] and the placebo subgroup [treated with PPIs, changing life style, and placebo]. After 3 months, we analyzed all data and the RDQ questionnaire was filled out for each patient. This project has been registered in Iranian Registry of Clinical Trials (IRCT) and all data were analyzed using SPSS software version 21. RESULTS A total of 140 patients (81 women and 59 men) with mean age of 42.78±11.5 years were included with 70 patients in each group. The most frequent presentations were heart burn (45.7%), and acid regurgitation (39.3%). The RDQ scores decreased after intervention in both drug ( p < 0.001) and placebo groups ( p < 0.001), which were statistically significant. But the difference of RDQ scores between the drug group and placebo group was not statistically significant ( p =0.086). CONCLUSION Zinc supplementation cannot improve the severity of GERD.
کلیدواژه‌های انگلیسی مقاله Gastroesophageal Reflux,Zinc,Symptoms
نویسندگان مقاله افشین شفقی | afshin shafaghi


جلال حسن زاده | jalal hasanzadeh


فریبرز منصور قناعی | fariborz mansour ghanaei


فرحناز جوکار | farahnaz joukar


مریم یاسری | maryam yaseri


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1686
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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