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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۱۷، شماره ۱، صفحات ۴۹-۰
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عنوان انگلیسی Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study
چکیده انگلیسی مقاله Statement of the Problem: Herpes simplex virus (HSV) infection is one of the most common and debilitating oral diseases; yet, there is no standard topical treatment to control it. The extract of Aloe vera leaves has been previously reported to have anti-inflammatory, antibacterial, and also antiviral effects. There is no data on anti-Herpes simplex virus type 1 (HSV-1) activity of Aloe vera gel. Purpose : This study aimed to evaluate the anti-HSV-1 activity of Aloe vera gel in Vero cell line. Materials and Method: In this study, gel extraction and cytotoxicity of various increasing concentrations of Aloe vera gel (0.2, 0.5, 1, 2, and 5%) was evaluated in Dulbecco’s Modified Eagle Medium (DMEM) containing 2% fetal bovine serum (FBS). Having been washed with phosphate buffered saline, 50 plaque-forming units (PFU) of HSV-1 was added to each well. After 1 hour of incubation at 37°C, cell monolayers in 24 well plates were exposed to different increasing concentrations of Aloe vera gel. The anti-HSV-1 activity of Aloe vera gel in different concentrations was assessed by plaque reduction assays. Data were analyzed by using One-way ANOVA. Results : The cytotoxicity assay showed that Aloe vera in prearranged concentrations was cell-compatible. The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between two serial concentrations ( p > 0.05). One-way ANOVA also revealed no significant difference between the groups. The findings indicated a dose-dependent antiviral effect of Aloe vera. Conclusion : The findings showed significant inhibitory effect of 0.2-5% Aloe vera gel on HSV-1 growth in Vero cell line. Therefore, this gel could be a useful topical treatment for oral HSV-1 infections without any significant toxicity. Key Words: Aloe vera; Herpes Simplex Virus-1; Herbal Medicine; Antiviral; Cell Culture
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فهیمه رضازاده | fahimeh rezazadeh
dept. of oral and maxillofacial medicine, school of dentistry, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مریم مشاوری نیا | maryam moshaverinia
dept. of oral and maxillofacial medicine, school of dentistry, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد معتمدی فر | mohammad motamedifar
shiraz hiv aids research center, dept. of bacteriology and virology, medical school, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

منتظر alyaseri | montazer alyaseri
students’ research committee, school of dentistry, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1025
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نوع مقاله منتشر شده Original Articles
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