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The Archives of Bone and Joint Surgery، جلد ۴، شماره ۴، صفحات ۳۲۳-۳۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Potential Role of Local Estrogen in Enhancement of Fracture Healing: Preclinical Study in Rabbits |
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| چکیده انگلیسی مقاله |
Background: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of local and systemic administration of estrogen on the fracture healing process. Methods: Standardized tibial fractures with 4 millimeter gaps were created in twenty four adult male Dutch rabbits. Fractures were fixed using intramedullary wires and long leg casts. Rabbits were randomly divided into three groups. Group A was treated with twice a week administration of long acting systemic estrogen; group B was treated with a similar regimen given locally at the fracture gap; and group C received sham normal saline injections (control). Fracture healing was assessed at six weeks post fracture by gross examination, radiographic and histomorphometric analysis. Results: Group B had significantly higher gross stability, radiographic ::union:: and gap reduction than the two other groups. Histomorphometric analysis showed higher cartilaginous proportion of periosteal callus area in the control group. Conclusions: Our results showed that estrogen may enhance fracture healing of long bone in rabbits. Furthermore, local estrogen treatment might have better effect than systemic treatment. |
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| کلیدواژه‌های انگلیسی مقاله |
Local estrogen, Fracture healing, Preclinical study, Rabbit |
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| نویسندگان مقاله |
محمد تهامی | mohammad tahami
bone and joint research centre, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
بهروز حداد | behrooz haddad
university college london hospital, 235 euston road, london, nw1 2bu uk
آرمین ابطحیان | armin abtahian
bone and joint research centre, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
علی هاشمی | ali hashemi
bone and joint research centre, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
امیر امینیان | amir aminian
bone and joint research centre, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
sujith konan | sujith konan
university college london hospital, 235 euston road, london, nw1 2bu uk
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| نشانی اینترنتی |
http://abjs.mums.ac.ir/article_7536.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
RESEARCH PAPER |
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