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International Journal of Pediatrics، جلد ۳، شماره ۲.۲، صفحات ۵۵۵-۵۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of HLA-DRB1 Alleles in Juvenile-onset Systemic Lupus Erythematosus (SLE) in Iranian Children |
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| چکیده انگلیسی مقاله |
Introduction Systemic Lupus Erythematosus (SLE) is a complex autoimmune and inflammatory disease. Many studies show HLA alleles can be associated with SLE. The aim of this study was to determine the association of HLA-DRB1 alleles with juvenile- onset in Iranian children. Materials and Methods At a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to Mofid Children’s Hospital, Shahid Behehsti University of Medical Sciences, Tehran, and 56 healthy children (control group) were participant. Genomic DNA was extracted and HLA typing was performed by Polymerase Chain Reaction (PCR) with Sequence - Specific Primers (SSP) technique. Results HLA- DRB1*01, HLA- DRB1*04, HLA- DRB1*11 and HLA- DRB1*13 were detected to as most frequent alleles associated with SLE in Iranian children. The frequency of HLA DRB1*08 was not significantly different in both groups (P>0.05(. HLA- DRB1*07 had a higher rate of repetition in the control group than patients with SLE. Conclusion There was a significant difference in the frequency of some alleles between patients and controls group, which could be related to susceptibility to SLE. These differences between frequencies of some alleles in both groups may help to determine the onset of lupus in children. |
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| کلیدواژه‌های انگلیسی مقاله |
Autoimmune, HLA- DRB1, PCR-SSP, Systemic Lupus Erythematosus |
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| نویسندگان مقاله |
شیرین فریور | shirin farivar
genetic department, faculty of biological sciences, shahid beheshti university, general campus, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
مسعود دهقان طزرجانی | masoud dehghan tezerjani
genetic department, faculty of biological sciences, shahid beheshti university, general campus, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
رضا شیاری | reza shiari
department of pediatrics, mofid children’s hospital, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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| نشانی اینترنتی |
http://ijp.mums.ac.ir/article_4234.html |
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| زبان مقاله منتشر شده |
en |
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