| چکیده انگلیسی مقاله |
Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional project in Pediatrics Neurology ward of a Tertiary Academic Hospital (Ghaem Hospital, Mashhad-Northeastern Iran). All children who needed valproic acid therapy alone were selected for study. Liver function test was performed for them at the beginning of VPA administration, three and six months after VPA, respectively. Data was analyzed by SPSS version 16. Results 60 children with mean age of 49±28.6 months were entered the study. 37 of them were male and 23 were female. 5% (3 children) were mental retard and 11.7% (7 patients) had neurologic or developmental deficit. Mean value of Aspartate Aminotransferase (AST), Alanine Transferase (ALT) and Alkaline phosphatase (ALP) were 27, 30.8 and 30.4 and 17.4, 20.7 and 22.8 and 425, 426 and 441 at the beginning of VPA administration, three and six months after VPA, respectively. In six months of our follow up, only one child (1.7%) had elevated liver transaminases. Conclusion Regard to our findings and its agreement with previous researches, it is important to control adverse drug events by measuring liver transaminases during antiepilepsy treatment. |
| نویسندگان مقاله |
جواد آخوندیان | javad akhondian
professor of pediatric neurology ward, faculty of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
محمد علی کیانی | mohammad ali kiani
assosiate professor of pediatrics gastroenterology , department of pediatrics, faculty of medicine, mashhad university of medical sciences , mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
سید علی جعفری | seyed ali jafari
assosiate professor of pediatrics gastroenterology , department of pediatrics, faculty of medicine, mashhad university of medical sciences , mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
مهران بیرقی طوسی | mehran beiraghi toosi
assistant professor of pediatric neurology ward, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
منصوره میرزایی نجم آباد | mansoureh mirzaei najm abad
resident of pediatric, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
حمید آهنچیان | hamid ahanchian
department of pediatrics, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
حمیدرضا کیانی فر | hamidreza kianifar
department of pediatrics, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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