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Asia Pacific Journal of Medical Toxicology، جلد ۳، شماره ۴، صفحات ۱۶۳-۱۶۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
HPLC Measurement of MDMA Content in Ecstasy Tablets Available in the Black Market of West Azerbaijan Province, Northwestern Iran |
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| چکیده انگلیسی مقاله |
Background:Ecstasy, mainly composed of 3,4-methylenedioxymethamphetamine (MDMA), is one of the most popular addictive synthetic drugs. This study was aimed to investigate the amount of MDMA in the ecstasy tablets seized in West Azerbaijan province, northwest Iran and also to assess the relationship between the physicochemical and morphological characteristics of the tablets. Methods: MDMA content of ecstasy tablets was analyzed using high-performance liquid chromatography method. Flow rate was 3 mL/min and mobile phase consisted of a mixture of acetonitrile and water containing triethylamine (pH = 3.2). The fluorescence spectrophotometer detector set at an excitation and emission wavelength of 220 and 306 nm, respectively. The retention time of ecstasy on this system was 2.2 minutes. The calibration curve was linear (R2= 0.999) over the concentrations ranging from 0.2 to 2 µg/ml. The limit of detection and the limit of quantitation were found to be 0.06 µg/L and 0.19 µg/L, respectively with six times repetition. Results: In this study, 85 ecstasy tablets were analyzed. Mean weight of the tablets was 275.6 ± 70.4 (range: 158.5-403.3) mg. Mean MDMA content of the tablets was 30.53 ± 23.23 (range: 0.05-70.7) mg. The tablets were classified into 8 groups based on their morphological features (color and logo). Considering the tablet groups, physicochemical features of the tablets (weight, MDMA content, and MDMA to weight ratio) were significantly different (P < 0.001). Correlation analysis showed that the MDMA content and weight of tablets were significantly correlated (P = 0.04). Conclusion: There is variability in the physicochemical properties of ecstasy tablets available in the black market for illicit drugs in northwest Iran. This variability may potentially put abusers at increased risk of overdose due to inadvertent excess ingestion of the tablets to achieve desired effects and also experiencing more harm due to tablets adulterants. |
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| نویسندگان مقاله |
رضا غفاری | reza ghafari
department of basic sciences, science and research branch, islamic azad university, hesarak, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
امیر حیدری | amir heydari
department of pharmacology, faculty of pharmacy, urmia university of medical science, urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
محمدرضا وردست | mohammad reza vardast
department of medicinal chemistry, faculty of pharmacy, urmia university of medical sciences, urmia, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
اعظم اکبری | azam akbari
department of medicinal chemistry, center for cellular and molecular research, urmia university of medical sciences, urmia, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
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| نشانی اینترنتی |
http://apjmt.mums.ac.ir/article_3844.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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