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Iranian Red Crescent Medical Journal، جلد ۱۸، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Long-Term Exposure of Lead Acetate on Rabbit Renal Tissue |
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| چکیده فارسی مقاله |
Results Long-term exposure to lead acetate caused histopathology effects including dilatation, congestion, nuclei heterochromatic effects, increase in diameter of renal tubules and urinary barrier thickness in rabbit renal tissue. Conclusions Quantitative and qualitative results of long-term lead acetate exposure showed many histopathology side-effects, especially in the urinary barrier. Materials and Methods In this experimental study, 20 male New Zealand rabbits were divided into control and test groups (10 in each). The test group was injected intraperitoneally with chronic dose (8.5 mg/kg of body weight) of lead acetate and for the control group the same volume of normal saline was used, every other day for 10 weeks. After anesthetizing, the biopsies of renal tissues were taken for light and electron microscopic morphometric and morphologic analyses. Objectives Although many histological and biochemical studies have reported about the effects of lead on the renal tissue, there are a few studies about the ultrastructure and morphometric effects of lead on the kidney. Hence, the aim of this study was the evaluation of morphology and morphometrics of rabbit renal urinary barrier ultrastructure following long-term exposure to lead acetate. Background Lead has been widely used in different industries for ages. It is one of the heavy metals, highly poisonous even at low doses, and has biochemical, physiological and behavioral side effects on human and animals. It has been shown that lead has toxic effects on different tissues such as neural and genitourinary tissues, cardiovascular systems and blood. Therefore, high attention has been paid to its environmental pollutions. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Long-Term Exposure of Lead Acetate on Rabbit Renal Tissue |
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| چکیده انگلیسی مقاله |
Results Long-term exposure to lead acetate caused histopathology effects including dilatation, congestion, nuclei heterochromatic effects, increase in diameter of renal tubules and urinary barrier thickness in rabbit renal tissue. Conclusions Quantitative and qualitative results of long-term lead acetate exposure showed many histopathology side-effects, especially in the urinary barrier. Materials and Methods In this experimental study, 20 male New Zealand rabbits were divided into control and test groups (10 in each). The test group was injected intraperitoneally with chronic dose (8.5 mg/kg of body weight) of lead acetate and for the control group the same volume of normal saline was used, every other day for 10 weeks. After anesthetizing, the biopsies of renal tissues were taken for light and electron microscopic morphometric and morphologic analyses. Objectives Although many histological and biochemical studies have reported about the effects of lead on the renal tissue, there are a few studies about the ultrastructure and morphometric effects of lead on the kidney. Hence, the aim of this study was the evaluation of morphology and morphometrics of rabbit renal urinary barrier ultrastructure following long-term exposure to lead acetate. Background Lead has been widely used in different industries for ages. It is one of the heavy metals, highly poisonous even at low doses, and has biochemical, physiological and behavioral side effects on human and animals. It has been shown that lead has toxic effects on different tissues such as neural and genitourinary tissues, cardiovascular systems and blood. Therefore, high attention has been paid to its environmental pollutions. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
محمد حسن کریم فر | mohammad hassan karimfar
department of anatomy, faculty of medicine, zahedan university of medical sciences, zahedan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
افشار بارگاهی | afshar bargahi
the persian gulf marine biotechnology research centre, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
داراب مشتاقی | darab moshtaghi
departments of surgery, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
پرویز فرزادی نیا | parviz farzadinia
department of biology and anatomical sciences, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran; department of biology and anatomical sciences, faculty of medicine, bushehr university of medical sciences, p. o. box 3631, bushehr, ir iran. tel fax 98-7733450692
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
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| نشانی اینترنتی |
http://www.ircmj.com/index.php?page=article&article_id=22157 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.5812/ircmj.22157 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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