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Iranian Journal of Veterinary Medicine، جلد ۷، شماره ۱، صفحات ۷-۱۳
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عنوان انگلیسی Effects of mesenchymal stem cells with injectable scaffold on cardiac function in myocardial infarction in Rabbit
چکیده انگلیسی مقاله BACKGROUND: Bone marrow-derived mesenchymal cellscan transdifferentiate into Cardiomyocyte cells and improveheart function after transplantation. Since biomaterials canimprove the cell retention in the site, cell survival and differentiation,heart tissue engineering is now being explored as anapplied solution to support cell-based therapies and increasetheir efficacy for myocardial diseases. Chitosan in combinationwith Glycerol Phosphate (GP) can produce a thermo sensitivematerial that in body temperature can form a jellylike material.OBJECTIVES:The aim of this study was to evaluate the effects ofa combination of autologous undifferentiated bone marrowmesenchymal stem cells (MSCs) and injectable scaffold on cardiacfunction improvement in rabbits after inducing myocardialinfarction. METHODS: The Left Anterior Descending (LAD)coronary artery was ligated by No. 6-0 polyamide suturematerial, and autologous MSCs with injectable scaffold wereinjected into the margins of the infarcted zone at the time ofsurgery. At 4 weeks after transplantation, the cardiac functionand structure was detected using echocardiography. RESULTS:There was no significant difference among the three groups (MIonly, MI Scaffold, and MI+Scaffold+MSCs) in the Echocardiographicparameters including, heart rate (HR), Ejection Fraction(EF), Fractional Shortening (FS), Left Ventricular Diameter(LVD) and Left Ventricular Parietal Wall Diameter (LVPW).CONCLUSIONS: A combination of autologous undifferentiatedbone marrow MSCs and injectable scaffold made of Chitosan+Glycerol Phosphate in echocardiographic evaluation did nothave a positive influence on achieving functional improvement.
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نویسندگان مقاله Nazanin Jafari |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Mohammad Mahdi Dehghan |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Mohammad Abarkar |
Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran

Mohammad Hejazi |
Department of Animal Sciences, Faculty of Agriculture, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran

Pegah Abbasnia |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Mohammad Molazem |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Amir Tavakoli |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Rouh-allah Mehdinavaz Aghdam |
Nanotechnology Department, Engineering Research Institute, Tehran, Iran

Seyed Hosein Ahmadi Tafti |
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Parviz Tajik |
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

نشانی اینترنتی https://ijvm.ut.ac.ir/article_32018_79e1ddedcc421480fe1cdee3769a13ce.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/466/article-466-1095494.pdf
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