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International Journal of Community Based Nursing and Midwifery، جلد ۴، شماره ۱، صفحات ۶۹-۰
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عنوان انگلیسی Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial
چکیده انگلیسی مقاله Background: Vaginal atrophy is a common complication in menopause which does not improve with time and, if untreated, can affect the quality of life for women. The aim of this study was to compare the effectiveness of the vaginal cream of hyaluronic acid and conjugated estrogen (Premarin) in treatment of vaginal atrophy. Methods: This study was a randomized controlled clinical trial on 56 menopausal women with symptoms of vaginal atrophy; they were randomly allocated to two groups (recipient conjugated estrogen and hyaluronic acid). The severity of each sign of atrophy was evaluated by visual analog signals (VAS) and on the basis of a four point scale. Also to recognize the cellular maturation with pap smear and the maturation degree were calculated according to the formula and scores 0-100. As to the vaginal PH, we used PH marker band, the rate of which was divided into 4 degrees. Data were analyzed using SPSS, version 20, and P≤0.05 was considered as significant. Results: The results of this study showed that the symptoms of vaginal atrophy compared with the baseline level were relieved significantly in both groups. Dryness, itching, maturation index, PH and composite score of the vaginal symptoms were relieved significantly in both groups (P< 0.001). Dyspareunia in Premarin (P< 0.05) and hyaluronic acid (P< 0.001) decreased compared with pre-treatment. Urinary incontinence only showed improvement in the hyaluronic acid group (P< 0.05). Improvement in urinary incontinence, dryness, maturation index (P< 0.05) and composite score of vaginal symptoms (P< 0.001) in the hyaluronic acid group was better than those in the Premarin group. Conclusion: According to the results of the present study, hyaluronic acid and conjugated estrogen improved the symptoms of vaginal atrophy. But hyaluronic acid was more effective and this drug is suggested for those who do not want to or cannot take local hormone treatment. Trial Registration Number: IRCT2013022712644N1
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نویسندگان مقاله اعظم جوکار | azam jokar
community based psychiatric care research center, department of midwifery, school of nursing and midwifery, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

طیبه داوری | tayebe davari
department of midwifery, school of nursing and midwifery shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نسرین اسدی | nasrin asadi
department of obstetrics and gynecology, school of medicine and maternal-fetal medicine research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

فاطمه احمدی | fateme ahmadi
department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

صدیقه فروهری | sedighe foruhari
community based psychiatric care research center, department of midwifery, school of nursing and midwifery, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijcbnm.sums.ac.ir/index.php/ijcbnm/article/view/332
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