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International Journal of Molecular and Cellular Medicine، جلد ۳، شماره ۱، صفحات ۲۶-۳۴
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عنوان انگلیسی Evaluation of pre-treatment serum levels of IL-7 and GM-CSF in colorectal cancer patients
چکیده انگلیسی مقاله Background: Survival of Colorectal cancer (CRC) patients is considerably stage-dependent therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. GM-CSF and IL-7 are reported to increase in different cancers and we aim to investigate the pre-treatment serum levels of GM-CSF and IL-7 in Iranian patients with colorectal cancer. Methods: 127 patients (68 males and 59 females) before receiving chemotherapy or radiotherapy entered to this study. A control group of 50 healthy age/sex matched individuals (27 males and 23 females) were included in the study. Serum levels of GM-CSF and IL-7 were measured using commercial enzyme linked immunosorbent assays. Results: A significantly higher level of GM-CSF was found in the sera of patients with colorectal cancer compared with healthy age/sex matched controls (p=0.013). However, there was no significant difference between the levels of IL-7 in sera of patients and controls. We observed a significant elevation in the level of GM-CSF in poorly differentiated tumors (p=0.024). Also a significant correlation between lymphatic invasion and the level of GM-CSF in sera of CRC patients was detected (p=0.01). We found an increase in the level of IL-7 in the three patients in the moderate stages of the tumor concomitant with a decrease in the level of GM-CSF. Conclusion: Increase in the level of GM-CSF is accompanied by CRC progression in Iranian patients, while there may be a potential therapeutic effect of IL-7 in this disease.
کلیدواژه‌های انگلیسی مقاله Colorectal cancer, Serum, GM-CSF, IL-7
نویسندگان مقاله مهدی تقی پور فرد اردکانی | mehdi taghipour fard ardekani
shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مهیار ملک زاده | mahyar malekzadeh
shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سید وحید وحید حسینی | seyyed vahid vahid hosseini
colorectal research center, faghihi hospital, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

الهه بردبار | elahe bordbar
shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

عباس قادری | abbas ghaderi
shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
سازمان های دیگر: Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

| mohammad hosein baghianimoghadam
professor, social determinants of health research center, shahid sadoughi university of medical sciences, yazd, ir iran
نشانی اینترنتی http://www.ijmcmed.org/browse.php?a_code=A-10-150-1&slc_lang=en&sid=en
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