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World Journal of Plastic Surgery، جلد ۵، شماره ۳، صفحات ۲۶۵-۲۷۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Superficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy Under Limited Access and Conventional Dressings |
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| چکیده انگلیسی مقاله |
BACKGROUND Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. This study determines superficial burn wound healing with intermittent negative pressure wound therapy under limited access and conventional dressings METHODS A total 50 patients were randomised into two equal groups: limited access and conventional dressing groups. Selective biochemical parameters such as hydroxyproline, hexosamine, total protein, and antioxidants, malondialdhyde (MDA), wound surface pH, matrix metalloproteinase-2 (MMP-2), and nitric oxide (NO) were measured in the granulation tissue. Histopathologically, necrotic tissue, amount of inflammatory infiltrate, angiogenesis and extracellular matrix deposition (ECM) were studied to determine wound healing under intermittent negative pressure. RESULTS Patients treated with limited access have shown significant increase in the mean hydroxyproline, hexosamine, total protein, reduced glutathione (GSH), glutathione peroxidase (GPx), and decrease in MDA, MMP-2, wound surface pH, and NO. Histopathologic study showed that there was a significant difference after 10 days of treatment between limited access vs conventional dressing group, Median (Q1, Q3)=3 (2, 4.25) vs 2 (1.75, 4). CONCLUSION Limited access was shown to exert its beneficial effects on wound healing by increasing ground substance, antioxidants and reducing MMP-2 activity, MDA, NO and providing optimal pH, decreasing necrotic tissue, amount of inflammatory infiltrate, increasing ECM deposition and angiogenesis. |
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| نویسندگان مقاله |
thittamaranahalli muguregowda honnegowda muguregowda | thittamaranahalli muguregowda honnegowda muguregowda
department of plastic surgery and burns, kasturba medical college, manipal, karnataka, india
echalasara govindarama padmanabha udupa | echalasara govindarama padmanabha udupa
department of biochemistry, kasturba medical college, manipal, karnataka, india;
pragna رایو | pragna rao
department of plastic surgery and burns, king abdul aziz specialist hospital, sakaka, al-jouf, saudia arabia;
pramod کومار | pramod kumar
department of biochemistry, kasturba medical college, manipal, karnataka, india;
rekha سینگ | rekha singh
department of pathology, kasturba medical college, manipal, karnataka, india
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| نشانی اینترنتی |
http://www.wjps.ir/browse.php?a_code=A-10-152-1&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
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