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Avicenna Journal of Phytomedicine، جلد ۲، شماره ۱، صفحات ۳۹-۴۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of nitric oxide or opioid receptors involvement in antinociceptive properties of silymarin |
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| چکیده انگلیسی مقاله |
Objective: It has been shown that Silybum marianum or its extracts have hepatoprotective, antioxidant, anticancer, anti-inflammatory and anti-diabetic effects. Nitric oxide (NO) plays an important role in neurotransmission, neuroprotection, neurotoxicity and pathological pain, as a neurotransmitter or neuromodulator in the central nervous system. Therefore, this experiment was performed in order to assess the analgesic effects of single and multiple-dosed ip administration of silymarin and the probable role of nitric oxide or opioid receptors using tail flick assay. Results: Based on our results, only silymarin 100 mg/kg showed analgesic properties. Since naloxone did not change silymarin’s analgesic effects, it is concluded that opioid receptors are not involved. Although in the presence of L-arginine, analgesic effect of silymarin remained intact, but it is not possible to strongly determine the involvement of nitric oxide pathway here. Based on our results, the difference between anti nociceptive properties of single and multiple-dosed treatment of silymarin 100 mg/kg is not significant. Conclusion: It is concluded that silymarin exert its analgesic effects via other mechanisms. Inhibiting 5-lipooxygenase and neutrophil chemotaxis to inflammation location could be the probable ways of silymarin’s action. |
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| کلیدواژه‌های انگلیسی مقاله |
Silymarin, Tail flick, L-NAME, Opioid receptors |
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| نویسندگان مقاله |
محسن ایمن شهیدی | mohsen imenshahidi
pharmaceutical research center and pharmacy school, mashhad university of medical sciences, i. r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
رامین رضایی | ramin rezaee
medical toxicology research center and pharmacy school, mashhad university of medical sciences, i. r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
امین مستوفی | amin mostofi
medical toxicology research center and pharmacy school, mashhad university of medical sciences, i. r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
غلامرضا کریمی | gholamreza karimi
medical toxicology research center and pharmacy school, mashhad university of medical sciences, i. r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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| نشانی اینترنتی |
http://ajp.mums.ac.ir/article_27.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Research Article |
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