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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۵، صفحات ۳۵۴-۳۶۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet |
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| چکیده انگلیسی مقاله |
Objectives: Cow urine ark (CUA), known as “Amrita” as mentioned in Ayurveda, contains anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid lowering activity of CUA and its possible implication in metabolic syndrome. Materials and Methods: Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle and sham control, received normal and high fat diet for 60 days respectively; Group 3, 4 and 5 received high fat diet for 60 days with CUA 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) on thelast 30 days of study period, respectively. Serum lipid profile (total cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C, total Cholesterol/HDL-C) and serum enzymes (ALT, AST, ALP, LDH and CK-MB) were performed in each group at the beginning and end of the study. Histological study of liver and kidney was done in each group. Results: CUA (0.8 ml/kg) significantly decreased the serum triglycerides and VLDL-C, but CUA (1.6 ml/kg) decreased the total serum Cholesterol, triglycerides and VLDL-C (p < 0.05). Higher dose (1.6 ml/kg) of CUA also increased HDL-C level, significantly (p < 0.05). CUA reduced serum AST, ALP and LDH level, which was statistically significant as well, while it also decreased the accumulation of lipid in hepatocytes as compared to sham control. Conclusions: CUA reduced triglycerides, increased HDL-C and found to be hepatoprotective in animals that are on a high fat diet. |
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| نویسندگان مقاله |
hiren manubhai chawda | hiren manubhai chawda
department of pharmacology, government medical college, bhavnagar-364001, gujarat, india
divyesh rasiklal mandavia | divyesh rasiklal mandavia
department of pharmacology, government medical college, bhavnagar-364001, gujarat, india
seema natvarlal baxi | seema natvarlal baxi
department of pathology, government medical college, bhavnagar-364001, gujarat, india
vishalkumar kishorbhai vadgama | vishalkumar kishorbhai vadgama
department of pharmacology, government medical college, bhavnagar-364001, gujarat, india
chandrabhanu rajkishor tripathi | chandrabhanu rajkishor tripathi
department of pharmacology, government medical college, bhavnagar-364001, gujarat, india
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| نشانی اینترنتی |
http://ajp.mums.ac.ir/article_3036.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Research Article |
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