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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۳، صفحات ۲۳۸-۲۴۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Hepatoprotective activity of aerial parts of Otostegia persica against carbon tetrachloride-induced liver damage in rats |
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| چکیده انگلیسی مقاله |
Objective: To evaluate the hepatoprotective properties of Otostegia persica (O. persica) ethanol extract on carbon tetrachloride-induced liver damage in rats. Materials and Methods: Fifty adult male Wistar rats were randomly divided into five groups. Group I served as normal control and was given only olive oil intraperitoneally (i.p.). Group II, III, IV, and V were administered CCl4 mixed with olive oil 1:1 (1 ml/kg) i.p., twice a week for 8 weeks. Group II was maintained as CCl4-intoxicated control (hepatotoxic group). Group III, IV, and V received O. persica extract at a dose of 40, 80, and 120 mg/kg for 8 weeks every 48 h orally, respectively. Biochemical parameters including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), albumin (ALB), total protein (TP), and lipid peroxidation marker (Malonaldialdehyde, (MDA) were determined in serum. After 8 weeks, animals were sacrificed, livers dissected out, and evaluated for histomorphological changes. Results: The administration of CCl4 increased AST, ALT, ALP, TB, and MDA in serum but it decreased TP , and ALB compared with normal control. Treatment with O. persica extract at three doses resulted in decreased enzyme markers, bilirubin levels, and lipid peroxidation marker (MDA) and increased TP and ALB compared with CCl4 group. The results of pathological study also support the hepatoprotective effects which were observed at doses of 80 and 120 mg/kg. Conclusion: The results of the present study indicate that ethanol extract of O. persica may have hepatoprotective effect which is probably due to its antioxidant property. |
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| نویسندگان مقاله |
مهدی اکبرتبار طوری | mehdi akbartabar toori
social determinants of health research center, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
بهزاد جودی | behzad joodi
student research committee, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
هیبت اله صادقی | heibatollah sadeghi
cellular and molecular research center, faculty of medicine, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
حسین صادقی | hossein sadeghi
department of pharmacology, faculty of medicine, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
مهرزاد جعفری | mehrzad jafari
cellular and molecular research center, faculty of medicine, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
محمد شریف طالبیان پور | mohammad sharif talebianpoor
department of pharmacology, faculty of medicine, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
فواد مهربان | foad mehraban
student research committee, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
مصطفی مصطفی زاده | mostafa mostafazadeh
student research committee, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
مهدی قوامی زاده | mehdi ghavamizadeh
student research committee, yasuj university of medical sciences, yasuj, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)
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| نشانی اینترنتی |
http://ajp.mums.ac.ir/article_4137.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Research Article |
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