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Journal of Kerman University of Medical Sciences، جلد ۲۵، شماره ۳، صفحات ۲۱۳-۲۲۷
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عنوان انگلیسی Synthesis and Biological Evaluation of 4-hydroxychromenyl arylmethyl-6-hydroxy pyrimidine-2, 4-dione Derivatives
چکیده انگلیسی مقاله Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4-hydroxychromenylarylmethyl-6-hydroxypyrimidine-2,4-diones is described. Method: The reactants were successfully condensed via three C-C bond formation by zinc oxide nanowires (ZnO NWs) as an efficient, environmentally safe and recyclable nano catalyst to produce target molecules. In addition, the biological effects of synthesized products by the use of DPPH and acyclovir as positive controls and also Hep-2, vero cell, HSV-1, and adenovirus as four applied cell lines have been evaluated. Results: The results showed that synthesized products have anti-oxidant, cytotoxic and anti-viral activities and can offer promising prospect as biologically active agents. Conclusion: This achievement in an efficient and eco-friendly synthesis of novel analogous of hybrid molecules in aqueous media with special biological properties may engross chemists and pharmacologists as well as pharmacists in future.
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نویسندگان مقاله Khalil Eskandari |
Assistant Professor, Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

Bahador Karami |
Professor, Department of Chemistry, Faculty of Basic Sciences, Yasouj University, Yasouj, Iran

Yaghoub Pourshojaei |
Assistant Professor, Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

Zahra Lori-Gooini |
Assistant Professor, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Elham Soltanipour-Joneghani |
Student's research committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

Mohammad-Taghi Moradi |
Assistant Professor, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Ali Asadipour |
Professor, Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی http://jkmu.kmu.ac.ir/article_76878_872912864982d4b1a173587315d851f7.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-1007418.pdf
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