International Journal of Pediatrics، جلد ۶، شماره ۱۱، صفحات ۸۵۰۷-۸۵۱۶
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عنوان انگلیسی Normal Saline vs. Hypertonic Saline Nebulization for Acute Bronchiolitis: A Randomized Clinical Trial
چکیده انگلیسی مقاله BackgroundWe aimed to compare the efficacy of nebulized hypertonic (3%, 5% and 7%) saline with normal saline in hospitalized infants with acute bronchiolitis.Materials and MethodsIn this triple-blinded randomized clinical trial, 120 children with moderate to severe bronchiolitis randomly assigned into four groups to receive nebulized normal saline (group A),  saline 3% (group B), saline 5% (group C), and saline 7% (group D). The length of hospital stay (LOS) as primary outcome and the use of oxygen, temperature, oxygen saturation (SPO2), pulse rate (PR), respiratory rate (RR), and bronchiolitis severity score were measured in the beginning of the study and during hospitalization.ResultsThe mean age of patients was 5 + 0.423 months and 79 of them (65%) were male. The length of hospital stay (LOS), and use of oxygen supplementation was not different between group A and B (P=0.36), but significantly lower than group C and D (P< 0.001). Vital signs, improvement in severity score and oxygen saturation were similar between groups.ConclusionOur study demonstrated that nebulization with 3% hypertonic saline and 0.9% saline can significantly reduce hospitalization rate compared nebulization with 5% and 7% hypertonic saline.
کلیدواژه‌های انگلیسی مقاله Bronchiolitis, Children, Length of stay, Saline solution
نویسندگان مقاله | Mohsen Reisi
Pediatrics Pulmonology Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.


| Narges Afkande
Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.


| Hasan golmakani
Pediatric Neurology Department, Mashhad University of Medical Sciences, Mashhad, Iran.


| Majid Khademian
Pediatrics Gastroenterology Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
نشانی اینترنتی http://ijp.mums.ac.ir/article_11170.html
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