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Asia Pacific Journal of Medical Toxicology، جلد ۱۴، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The Effects of Androctonus crassicauda Scorpion Venom on Liver and Kidney Histopathology and Biochemical Factors in STZ-induced Diabetic Rats
چکیده انگلیسی مقاله Background: Type 2 diabetes (T2D) is a complex metabolic disorder characterized by insulin resistance and relative insulin deficiency, leading to chronic hyperglycemia. The potential therapeutic applications of scorpion venom have gained attention in recent years, particularly in the context of diabetes management. Therefore, our aim is to investigate the effect of A. crassicauda scorpion venom on biochemical factors of streptozotocin (STZ)-induced diabetic rats.Methods: In this study, diabetes was defined as any blood sugar level over 250 mg/dL in male Wistar rats induced by a single dose of streptozotocin intraperitoneally. The animals were divided into five groups, two of which received scorpion venom. Afterwards, the levels of blood glucose, cholesterol, triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), urea, creatinine, alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate aminotransferase (AST) were measured. In addition, histopathological changes in the liver and kidneys were assessed using hematoxylin and eosin (H&E) staining. Results: It was found that Androctonus crassicauda scorpion venom reduced blood sugar. Other biochemical factors were also decreased compared to the diabetic group, and histological analysis showed partial repair of degenerated liver and kidney cells after venom injection compared with diabetic rats not treated with venom.Conclusion: The results of this study indicate that the effect of Androctonus crassicauda scorpion venom on diabetes is positive and reduces diabetic symptoms. Therefore, scorpion venom may be a viable option for managing diabetes in the future. 
کلیدواژه‌های انگلیسی مقاله Androctonus crassicauda, Scorpion venom, Type 2 diabetes (T2D)
نویسندگان مقاله | Fateme Jafari
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mona Sharififard
Department of Vector Biology and Control of Disease, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Amir Mohamad Amiri
Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Nooshin Ghadiri
Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mohammad Nemati
Department of Venomous Animals and Anti-venom Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Ahvaz, Iran
نشانی اینترنتی https://apjmt.mums.ac.ir/article_26158.html
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