Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۴، صفحات ۴۲۸-۴۳۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-oxidant and anti-inflammatory potential of aqueous extracts of leaves, barks and roots of Bixa orellana L. (Bixaceae) on acetaminophen-induced liver damage in mice
چکیده انگلیسی مقاله Objective: Bixa orellana is a plant from the Bixaceae family, for which, limited information is available on hepatoprotective properties. This study aimed at evaluating the protective effects of this plant on sub-acute acetaminophen (APAP)-induced liver injury in mice. Materials and Methods: Various aqueous extracts were prepared from roots, leaves, and barks. Albino mice were divided into six groups: a control group, an APAP group; a silymarin group (positive control) and three test groups. Mice were treated orally with APAP (250 mg/kg) followed 3 hr later by plant extracts, silymarin (50 mg/kg) or distilled water (10 ml/kg) administration once daily, for seven days. After treatment, animals were sacrificed, the liver was collected and different biochemical parameters were measured. Histological analyses were performed using hematoxylin/eosin staining and the qualitative phytochemical content of plant extracts was evaluated using conventional methods. Results: Administration of B. orellana barks decoction (250 mg/kg) significantly reduced alanine aminotransferase levels (p
کلیدواژه‌های انگلیسی مقاله Bixaceae, Anti-inflammatory agents, Antioxidant, Mice, Liver
نویسندگان مقاله | David Djibersou
Laboratory of Applied Biochemistry, Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454 Ngaoundere, Adamawa, Cameroon


| Borris Rosnay Galani Tietcheu
Laboratory of Applied Biochemistry, Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454 Ngaoundere, Adamawa, Cameroon


| Pascal Dieudonne Chuisseu
Basic Science Department, Faculty of Health Sciences, Université des Montagnes, PO Box 208 Bangangté, West, Cameroon


| Nicolas Njintang
Laboratory of Applied Biochemistry, Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454 Ngaoundere, Adamawa, Cameroon
نشانی اینترنتی http://ajp.mums.ac.ir/article_14380.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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