Journal of Kerman University of Medical Sciences، جلد ۲۷، شماره ۲، صفحات ۱۰۶-۱۱۲

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عنوان انگلیسی Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis
چکیده انگلیسی مقاله Methods: The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women.Methods: Serum and saliva 25(OH)D levels of 30 MS women and 30 matched healthy controls in this case-control study were measured by ELISA. Data were analyzed by unpaired two-tailed student’s t-test, Pearson correlation test and Receiver operating characteristic (ROC).Results: The mean levels of 25(OH)D in serum and in both stimulated and unstimulated saliva were significantly lower in patients with MS. Serum levels of 25(OH) significantly correlated with stimulated (r = 0.575; P=0.003) and unstimulated saliva (r = 0.548; P=0.004). The mean (±SD) EDSS was 3.6±1.9 in the MS group. EDSS was not significantly correlated with 25(OH)D in serum or in stimulated and unstimulated saliva. The cut-off points of 25(OH)D in serum and saliva were 18 ng/ml and 65 pg/ml, respectively.Conclusions: 25(OH)D level in saliva like in serum was low in MS women. Serum 25(OH)D levels correlated positively with saliva 25(OH)D in women suffering from MS.
کلیدواژه‌های انگلیسی مقاله Multiple sclerosis 25, Hydroxycholecalciferol Saliva

نویسندگان مقاله Mohammad-Reza Mirzaii-Dizgah |
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Mohammad-Hosein Mirzaii-Dizgah |
Student Research Committee, School of Dentistry, Aja University of Medical Sciences; Tehran, Iran

Iraj Mirzaii-Dizgah |
Professor Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran


نشانی اینترنتی http://jkmu.kmu.ac.ir/article_90613_07d41858e5c7a8084489015af2083971.pdf
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