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Journal of Kerman University of Medical Sciences، جلد ۲۷، شماره ۲، صفحات ۱۰۶-۱۱۲
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عنوان فارسی |
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
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چکیده انگلیسی مقاله |
Methods: The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women.Methods: Serum and saliva 25(OH)D levels of 30 MS women and 30 matched healthy controls in this case-control study were measured by ELISA. Data were analyzed by unpaired two-tailed student’s t-test, Pearson correlation test and Receiver operating characteristic (ROC).Results: The mean levels of 25(OH)D in serum and in both stimulated and unstimulated saliva were significantly lower in patients with MS. Serum levels of 25(OH) significantly correlated with stimulated (r = 0.575; P=0.003) and unstimulated saliva (r = 0.548; P=0.004). The mean (±SD) EDSS was 3.6±1.9 in the MS group. EDSS was not significantly correlated with 25(OH)D in serum or in stimulated and unstimulated saliva. The cut-off points of 25(OH)D in serum and saliva were 18 ng/ml and 65 pg/ml, respectively.Conclusions: 25(OH)D level in saliva like in serum was low in MS women. Serum 25(OH)D levels correlated positively with saliva 25(OH)D in women suffering from MS. |
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کلیدواژههای انگلیسی مقاله |
Multiple sclerosis 25, Hydroxycholecalciferol Saliva |
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نویسندگان مقاله |
Mohammad-Reza Mirzaii-Dizgah | Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Mohammad-Hosein Mirzaii-Dizgah | Student Research Committee, School of Dentistry, Aja University of Medical Sciences; Tehran, Iran
Iraj Mirzaii-Dizgah | Professor Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
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نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_90613_07d41858e5c7a8084489015af2083971.pdf |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-2416919.pdf |
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زبان مقاله منتشر شده |
en |
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