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Research Journal of Pharmacognosy، جلد ۷، شماره ۲، صفحات ۱۳-۲۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Anxiolytic and Antidepressant Effect of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats |
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| چکیده انگلیسی مقاله |
Background and objective: Epilepsy one the most prevalent neurological illness which affects behavioral statuses like anxiety, depression and balance. Based on the anti-inflammatory and antioxidant properties of Tanacetum polycephalum, its effect on anxiety and depression caused by pentylenetetrazole (PTZ)-kindling in rats was investigated. Methods : In order to prepare the required extract, aerial part of the Tanacetum was powdered (100 g) and macerated in 1 L of ethanol (80%) for 24 h. Twenty-four rats were randomly assigned to four groups: PTZ (sub-threshold dose 35 mg/kg for one month, intraperitoneal (i.p)), PTZ + phenobarbital (30 mg/kg, i.p), PTZ + Tanacetum extract (300 mg/kg, i.p), and PTZ + Tanacetum extract (600 mg/kg, i.p). Elevated plus maze (EPM), forced swim test (FST) and rotarod test were employed to assess the anxiety parameters, antidepressant and balance potential, respectively. Results: Tanacetum extract administered at the doses of 300, and 600 mg/kg, exert antidepressant-like activity in the FST test and reduced the immobility time. In the EPM test, Tanacetum extract at the same doses produced anxiolytic-like effects. Also, the rats which received Tanacetum extract showed a significant improvement in the rotarod test in contrast to the PTZ group. Conclusion: The finding from current study showed that Tanacetum could ameliorate neurobehavioral parameters of anxiety and depression in the PTZ-kindled rats. |
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| کلیدواژه‌های انگلیسی مقاله |
Anxiety, depression, Epilepsy, Pentylenetetrazole, Tanacetum |
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| نویسندگان مقاله |
Vahid Azizi |
Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Farzin Allahyari |
Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
Farnoosh Rezaali |
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Abdolkarim Hosseini |
Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
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| نشانی اینترنتی |
http://www.rjpharmacognosy.ir/article_103900_928b0859ec833a41d54d16521dcee2d2.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-2332170.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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