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Iranian Journal of Diabetes and Obesity، جلد ۳، شماره ۲، صفحات ۶۰-۶۴
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عنوان انگلیسی The Effect of Enalapril, an Angiotensin Converting Enzyme Inhibitor, on Diabetic Neuropathy: A Double Blind Random–Allocated Study
چکیده انگلیسی مقاله OBJECTIVE: Diabetes mellitus is one of the most common endocrine diseases with micro-vascular complications and is a common cause of polyneuropathy. We studied the effect of enalapril on electrophysiologic criteria and clinical symptoms of patients with type II diabetes and sensory neuropathy. MATERIALS AND METHODS: A double blind study was conducted on 45 Patients with type II diabetes and neuropathy. They were normotensive and randomly divided into case and control groups. The case group received oral enalapril 2.5 mg twice a day for 3 months. The control group received placebo. We evaluated the changes in symptoms and electrophysiologic findings. RESULTS: In case group distal latency of peroneal (p=0.01), tibial (p=0.2), ulnar motor (p< 0.001), ulnar sensory (p< 0.001), median sensory (p< 0.001), and median motor nerves (p=0.004) decreased. Amplitude of peroneal (p=0.01), tibial (p=0.01), ulnar motor (p< 0.001), ulnar sensory (p< 0.001), median sensory (p< 0.001) and median motor nerves (p< 0.001) increased. Electrophysioloic test of peroneal n. (p=0.01), tibial n. (p=0.01), ulnar motor n. (p< 0.001), ulnar sensory n. (p< 0.001), median sensory n. (p< 0.001) and median motor n. (p< 0.001) increased. We did not get any result about sural sensory potential at the beginning and the end of the study. Neuropathy symptom score was also decreased. (p=0.16) CONCLUSION: In case group electrophysiologic criteria of peroneal, tibial, median sensory and motor, and ulnar sensory and motor nerves showed significant improvement. But no significant changes were found in clinical symptoms.
کلیدواژه‌های انگلیسی مقاله Diabetic neuropathy, Enalapril, Electrophysiologic test
نویسندگان مقاله غلامرضا شمسایی | gholamreza shamsaei
1. neurology department, golestan hospital, ahvaz jundishapour university of medical sciences, ahvaz, iran


نسترن مجدی نسب | nastaran madjdinasab
1. neurology department, golestan hospital, ahvaz jundishapour university of medical sciences, ahvaz, iran


حاجیه بی بی شهبازیان | hajieh bibi shahbazian
2. diabetes research center, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مهدی نوروز سروستانی | mehdi norouz sarvestani
1. neurology department, golestan hospital, ahvaz jundishapour university of medical sciences, ahvaz, iran


ارمغان مروج آل علی | armaghan moravej aleali
2. diabetes research center, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-1-3&slc_lang=en&sid=en
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