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Iranian Journal of Diabetes and Obesity، جلد ۵، شماره ۴، صفحات ۱۶۳-۱۷۰
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عنوان انگلیسی Insulin Resistance in First-Degree Relatives of the Patients with Polycystic Ovarian Syndrome
چکیده انگلیسی مقاله Abstract Objective: Insulin resistance and hyperinsulinemia are common among the women with polycystic ovarian syndrome (PCOS). Familial aggregation of PCOS has implications on the role of heredity in this disease. The aim of this study was to evaluate insulin resistance among the fathers, mothers, and siblings of the women with PCOS referring to the clinics affiliated to Shiraz University of Medical Sciences. Materials and Methods: The present case-control study was conducted on 107 individuals as the case group and 107 individuals as the control group. After recording their height and weight, blood samples were obtained from all the participants in order to assay their serum insulin and blood sugar. Then, the participants were supposed to drink 75 gr glucose solutions and after lapsing 2 hours, blood samples were again taken from all the participants. Finally, the data were analyzed using independent t-test, Fisher's exact test, and chi-square test. P-values less than 0.05 were considered as statically significant. All the statistical analyses were performed through the SPSS statistical software (ver. 11.5). Results: A significant difference was found between the two groups regarding glucose intolerance, obesity, and insulin resistance according to Homeostasis Model Assessment Index (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI), and fasting insulin indexes (P< 0.05). Moreover, a significant association was observed between android obesity and glucose intolerance (P< 0.05), body mass index (≥ 30 Kg/m2), and type II diabetes in the two groups. Conclusion: The first-degree relatives of the women suffering from polycystic ovarian syndrome constitute a risk group and early identification of insulin resistance may prevent the onset and progression of the disease.
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نویسندگان مقاله مرضیه اکبرزاده | marzieh akbarzadeh
msc, community based psychiatric care research center, department of midwifery, school of nursing and midwifery, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

فرشته مرادی | fereshteh moradi
msc, midwife, university of medical sciences, shiraz, iran.


محمد حسین دباغ منش | mohammad hosein dabbagh manesh
md, professor, department of internal medicine, endocrine and metabolism research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نجف زارع | najaf zareh
phd of biostatistics, associate professor, infertility research center, shiraz university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد ابراهیم پارسا نژاد | mohammad ebrahim parsa nezhad
professor, department of obstetrics amp;amp; gynecology, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-63&slc_lang=en&sid=en
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