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Iranian Journal of Diabetes and Obesity، جلد ۵، شماره ۴، صفحات ۱۴۴-۱۵۰
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عنوان انگلیسی The Effects of Adding Spironolactone to ACEI or ARB on Proteinuria in Type 2 Diabetes
چکیده انگلیسی مقاله Abstract Objectives: Interruption of rennin-angiotensin-aldosterone system has become a leading therapeutic strategy in the treatment of diabetic nephropathy however, ACEIs and ARBs do not uniformly suppress the rennin-angiotensin-aldosterone system. Plasma aldosterone levels are elevated in a group of patients despite therapy and this phenomenon known as aldosterone escape or aldosterone break through. Materials and Methods: Forty-two type 2 diabetic patients with overt proteinuria were randomized into two groups and according to double-blind case-control study, one group was treated with spironolactone and others were treated with placebo for 4 months. Twenty-four hours urine protein, glomerular filtration rate (GFR) and blood pressure were measured at baseline and after 4 months of treatment. Serum potassium was checked at baseline and one month of treatment. Results: Urine protein decreased in case group by 26.5% at the end of 4 months, but increased in control group by 17.9% (P=0.003). GFR did not have any significant change in case group (P< 0.354), but decreased in case group significantly (P< 0.001). Conclusion: Our study showed that spironolactone 12.5 mg/day is safe (without hyperkalemia and gynecomastia) and effective to decrease proteinuria in diabetic patient with CKD1-2.
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نویسندگان مقاله فرزانه نجفی | farzaneh najafi
assistant professor division of nephrology, yazd diabetes research center, yazd. iran


بی بی سعیده رضوانی نژاد | bibi saideh rezvaninejad
resident of internal medicine, division of nephrology, department of internal medicine, shaheed sadoughi university of medical sciences and health services, yazd, iran.


سید محمد محمدی | seyed mohammad mohammadi
assistant professor of endocrinology, yazd diabetes research center, shahid sadoughi university of medical sciences, yazd, iran
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-60&slc_lang=en&sid=en
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