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Middle East Journal of Cancer، جلد ۱، شماره ۱، صفحات ۲۷-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients |
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| چکیده انگلیسی مقاله |
Introduction : Pancreatic cancer has not been well studied, especially in developing countries. Materials and Methods : We studied the variations in genetic mutations in pancreatic adenocarcinoma between Moroccan and Egyptian populations. The molecular pathology of 30 tumors from a large hospital in Casablanca, Morocco were examined and compared with the findings of 44 tumors from the Gharbiah Governate in Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons 5-8 were evaluated. Results : Overall, differences in the rates of K-ras mutations were not statistically significant (48.00 and 34.09%, respectively); however differences in rates of p53 mutations were statistically significant with p53 mutations more common in Moroccan tumors than in Egyptian tumors (46.67 and 16.28%, respectively). GTmutations of the K-ras gene were most commonly seen Egyptian tumors, whereas GAmutations were the most common type of mutations in Moroccan tumors. Logistic regression analysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5 predicted the country of residence and those mutations occurred more frequently in Moroccan patients. Conclusion : Our study shows that differences exist within the Arab population in the molecular pathology of both the K-ras and p53 genes. Further studies are necessary to clarify the differences in molecular pathways of pancreatic cancer in the Middle East and to investigate the role of environmental and/or genetic factors related to those pathways. |
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| نویسندگان مقاله |
سارا robinson | sara robinson
department of epidemiology, university of michigan school of public health, ann arbor, michigan, usa
amr s سلیمان | amr s soliman
department of epidemiology, university of michigan school of public health, ann arbor, michigan, usa
مهدی karkouri | mehdi karkouri
department of pathology, mohammed v university, casablanca, morocco
هدی gad omer | hoda gad omer
department of pathology, tanta cancer center, tanta, egypt
ژول f greenson | joel f greenson
department of pathology, university of michigan school of medicine, ann arbor, michigan, usa
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/107 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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