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Middle East Journal of Cancer، جلد ۳، شماره ۴، صفحات ۱۳۱-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study |
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| چکیده انگلیسی مقاله |
Background : We conducted a retrospective analysis to investigate the clinical outcome of combined modality therapy using multiagent chemotherapy, nephrectomy, and radiotherapy in treatment of children with Wilms' tumor. Methods : This study was conducted on 91 cases of newly diagnosed Wilms' tumor from January 2001 until February 2012. Patients were categorized into two groups according to treatment approach: i) preoperative chemotherapy with delayed surgery (group A; n=66) and ii) immediate surgery (group B; n=25). Results : Preoperative chemotherapy showed a 54.5% partial response rate in group A patients. A final stage distribution indicated that the majority of patients (64%) from both groups were considered to be in the early disease stages (I and II). The median follow up was 49 months (range 3-124). The five-year overall survival rate was 66.5%, whereas the event-free survival rate was 62.5%. In univariate analysis, factors associated with statistically significant reduction in overall (P24 months was associated with a significant reduction in the overall survival rate (P=0.038, HR: 0.438, 95% CI: 0.192-0.953), but was not significant in terms of event- free survival (P=0.104, HR: 0.539, 95% CI: 0.256-1.136). Age >24 months (P=0.0095), disease stage (P=0.0014), and blastimal subtype (P=0.006) were associated with significant increases in relapse rate. Conclusion : Preoperative chemotherapy resulted in a final stage redistribution that placed the majority of patients in the early stages of the disease. Age at diagnosis, disease stage, and histological subtype significantly affected survival and relapse rates. |
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| نویسندگان مقاله |
heba a سید | heba a sayed
pediatric oncology department, south egypt cancer institute seci , assiut university, assiut, egypt
مونا m سید | mona m sayed
radiation oncology department, south egypt cancer institute seci , assiut university, assiut, egypt
محمد i el سید | mohamed i el sayed
radiation oncology department, south egypt cancer institute seci , assiut university, assiut, egypt
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/38 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Middle East Special Report |
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