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Middle East Journal of Cancer، جلد ۵، شماره ۱، صفحات ۷-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Clinicopathological Significance of CD105 Expression in Squamous Cell Carcinoma of the Oral Cavity |
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| چکیده انگلیسی مقاله |
Background : Angiogenesis is essential for the growth, invasion and metastasis of solid tumors. Research on related factors such as microvessel density can be helpful in predicting a tumor's behavior. CD105 has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. There are some controversies about the relation of microvessel density and clinicopathological features of oral squamous cell carcinoma. The aim of this study is to determine the CD105 expression in oral squamous cell carcinoma and its relation to the clinicopathological features of this disease. Methods : We studied a total of 42 patients who had oral squamous cell carcinoma. The control group consisted of 15 cases with normal oral epithelium. CD105 immunostaining was performed on 4 μm thick tissue sections. Intratumoral and peritumoral microvessel density in ten areas of the sections were recorded by two pathologists. Results : There was a significantly higher CD105 microvessel density value in the tumoral tissues compared with normal tissues. In addition, there was more expression of this marker in the invasive front area. The CD105 microvessel density value had a positive relation with lymph node metastasis. There was an association between tumor size and CD105 microvessel density in the invasive front region. A negative association between tumor grade and CD105 microvessel density value in the intratumoral region was observed. In both areas, CD105 expression was higher in cases with advanced clinical stage. There was no association between this marker and patients' ages or gender. Conclusion : CD105 microvessel density can be a useful factor for predicting the course of oral squamous cell carcinoma. |
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| نویسندگان مقاله |
آزاده اندیشه تدبیر | azadeh andisheh tadbir
oral and dental health care research center, department of oral and maxillofacial pathology, school of dentistry, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
محمد جواد اشرف | mohammad javad ashraf
department of pathology, school of medicine, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
مینا مرادی | mina moradi
student research committee,school of dentistry, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/141 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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