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Middle East Journal of Cancer، جلد ۵، شماره ۲، صفحات ۵۵-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Role of T Regulatory Lymphocytes in Lymphoma |
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| چکیده انگلیسی مقاله |
T regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. T regulatory cells are produced in the thymus as a functionally mature subpopulation of T cells. They can be induced from naive T cells in the periphery and express their marker as a forkhead/winged helix transcription factor called FoxP3. In patients with lymphomas where T regulatory cells serve as suppressor anti-tumor cytotoxicity, decreased numbers of T regulatory cells are associated with a favorable prognosis. In contrast, in patients with lymphomas where T regulatory cells function as anti-tumor cytotoxic agents, enhanced numbers of T regulatory cells are associated with a favorable prognosis. Tumors actively promote the accumulation of these cells through several mechanisms that involve activation of naturally occurring T regulatory cells as well as conversion of non-T regulatory cells into T regulatory cells. Tumor-derived prostaglandin E2 can increase T regulatory cell activity and induce a regulatory phenotype in CD4+CD25+T cells. On the other hand, a balance between T regulatory and Th17 cells is essential for maintaining homeostasis of anti-tumor immunity. Accelerating processes such as increasing the amounts of IL-6 or IL-17 can enhance FoxP3 T regulatory cell expression and result in a lymphoma or inactivation of T cell CD4+. This effect is the reason for malignancy and a reduction in anti-tumor immune response. In this systematic review we intend to analyze this relationship. We have collected and analyzed the majority of recently published articles on the role of T regulatory cells as a review article. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
احمد ناصر | ahmad nasser
student research committee, ilam university of medical sciences, ilam, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
آرا خسروی | ara khosravi
associate professor of immunology, immunology dept., faculty of medicine, ilam university of medical sciences, ilam, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
محمد طاها گمراوی | mohamad taha gomravi
student research committee, ilam university of medical sciences, ilam, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
رضا عزیزیان | reza azizian
student research committee, ilam university of medical sciences, ilam, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/113 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article |
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